|本期目录/Table of Contents|

[1]徐玉林,张渊,娄振山综述,等.自杀行为的生物学研究进展[J].医学研究与战创伤救治(原医学研究生学报),2019,21(6):636-642.[doi:10.3969/j.issn.1672-271X.2019.06.018]
 XU Yu-lin,ZHANG Yuan,LOU Zhen-shan reviewing,et al.Research progress in biological basis of suicidal behavior[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(6):636-642.[doi:10.3969/j.issn.1672-271X.2019.06.018]
点击复制

自杀行为的生物学研究进展()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年6期
页码:
636-642
栏目:
综述
出版日期:
2019-11-14

文章信息/Info

Title:
Research progress in biological basis of suicidal behavior
文章编号:
1672-271X(2019)06-0636-07
作者:
徐玉林 张渊 娄振山综述 许涛审校
310007 杭州,空军杭州特勤疗养中心心理科
Author(s):
XU Yu-lin ZHANG Yuan LOU Zhen-shan reviewing XU Tao checking
(Department of Psychology, Air Force Health Care Center for Special Services Hangzhou, Hangzhou 310007, Zhejiang, China)
关键词:
自杀 5?羟色胺 脑源性神经营养因子 蛋白激酶A
Keywords:
suicide 5-hydroxytryptamine brain-derived neurotrophic factor protein kinase A
分类号:
R395.6
DOI:
10.3969/j.issn.1672-271X.2019.06.018
文献标志码:
A
摘要:
自杀是世界范围内一项严峻的公共卫生问题,也是青少年死亡的第二位因素。近来研究发现,自杀行为的发生存在特定的神经生物学基础。文章主要从5-羟色胺能系统、脑源性神经营养因子、下丘脑-垂体-肾上腺轴系统、受体耦联信号转导系统以及炎症细胞因子等的功能异常与自杀行为的相关性进行综述。
Abstract:
Suicide is a major public health concern worldwide, which is the second leading cause of death in adolescents. Recent studies have concluded that there is a specific neurobiological basis for the occurrence of suicidal behavior. This paper reviews the relationship between dysfunction of serotonergic system, brain-derived neurotrophic factor, hypothalamic-pituitary-adrenal axis system, receptor-coupled signal transduction system, and inflammatory cytokines, and suicidal behavior. Hopefully, this article provides a reference for further understanding of suicidal behavior, as well as provides ideas for suicide risk assessment, suicide prevention and treatment.

参考文献/References:

1 赵汉清,施建安,汪卫华. 美军在伊拉克战争中自杀的预防及对我军的启示[J].东南国防医药,20l0,12(1):91-93.
2 张理义,唐开宏,魏红辉,等.国防生有自杀意念者心身健康状况及其危险因素的研究[J].东南国防医药,2012,14(6):487-490.
3 HarrisEC, BarracloughB. Suicide as an outcome for mental disorders. A meta-analysis [J]. Br J Psychiatry,1997,170:205-228.
4 JoinerTE Jr, BrownJS, WingateLR. The psychology and neurobiology of suicidal behavior [J]. Annu Rev Psychol,2005,56:287-314.
5 van HeeringenC, AudenaertK, Van LaereK, et al. Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide [J]. J Affect Disord,2003,74:149-158.
6 LeeBH, KimYK. Potential peripheral biological predictors of suicidal behavior in major depressive disorder [J]. Prog Neuropsychopharmacol Biol Psychiatry,2011,35:842-847.
7 PandeyGN, RenX, RizaviHS, et al. Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims [J]. Int J Neuropsychopharmacol,2008,11:1047-1061.
8 PandeyGN, DwivediY. What can post-mortem studies tell us about the pathoetiology of suicide? [J] Future Neurol,2010,5:701-720.
9 PleinH, BerkM. The platelet as a peripheral marker in psychiatric illness [J]. Hum Psychopharmacol,2001,16:229-236.
10 孙双涛,牛威,沈佳懿,等. 5-羟色胺和胆固醇水平对抑郁症患者再次自杀风险评估的研究[J].精神医学杂志,20l4,27(5):337-339
11 TyanoS, ZalsmanG, OfekH, et al. Plasma serotonin levels and suicidal behavior in adolescents [J]. Eur Neuropsychopharmacol,2006,16:49-57.
12 RoggenbachJ, Muller-OerlinghausenB, FrankeL, et al. Peripheral serotonergic markers in acutely suicidal patients. 1. Comparison of serotonergic platelet measures between suicidal individuals, nonsuicidal patients with major depression and healthy subjects [J]. J Neural Transm,2007,114:479-487.
13 MarcinkoD, PivacN, MartinacM , et al. Platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with a first- episode of psychosis [J]. Psychiatry Res,2007,150:105-108.
14 KovacicZ, HenigsbergN. Platelet serotonin concentration and suicidal behavior in combat related post-traumatic stress disorder [J]. Prog Neuropsychopharmacol Biol Psychiatry,2008,32: 544-551.
15 AsbergM, TraskmanL, ThorenP. 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor [J]? Arch Gen Psychiatry,1976,33:1193-1197.
16 JokinenJ, NordstromAL, NordstromP. CSF 5-HIAA and DST non-suppression orthogonal biologic risk factors for suicide in male mood disorder inpatients [J]. Psychiatry Res,2009,165:96-102.
17 PandeyGN, PandeySC, JanicakPG, et al. Platelet serotonin-2 receptor binding sites in depression and suicide [J]. Biol Psychiatry,1990,28:215-222.
18 PandeyGN, DwivediY, RizaviHS, et al. Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims [J]. Am J Psychiatry,2002,159:419-429.
19 AudenaertK, Peerem ansK, Goethals, et al. Functional imaging, serotonin and the suicidal brain [J]. Acta Neurol Belg,2006,106:125-131.
20 LauterbachE, BrunnerJ, HawellekB, et al. Platelet 5- HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behavior [J]. J Affect Disord,2006,91:57-62.
21 PompiliM, GentileG, ScassellatiC, et al. Genetic association analysis of serotonin and signal transduction pathways in suicide attempters from an Italian sample of psychiatric patients[J]. Neurosci Lett, 2017,656:94-102.
22 StockmeierCA, ShapiroLA, Dilley GE, et al. Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity [J]. J Neurosci,1998,18:7394-7401.
23 BoldriniM, UnderwoodMD, MannJJ, et al. Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides [J]. J Psychiatr Res,2008,42:433-442.
24 GurevichI, TamirH, ArangoV, et al. Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims [J]. Neuron,2002,34:349-356.
25 DrachevaS, ChinB, HaroutunianV. Altered serotonin 2C receptor RNA splicing in suicide: association with editing [J]. Neuroreport,2008,19:379-382.
26 PandeyGN, DwivediY, RenX, et al. Regional distribution and relative abundance of serotonin(2c) receptors in human brain: effect of suicide [J]. Neurochem Res,2006,31:167-176.
27 UnderwoodMD, KassirSA, BakalianMJ, et al. Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity[J]. Transl Psychiatry,2018,8(1):279.
28 BalciogluYH, KoseS. Neural substrates of suicide and suicidal behaviour: from a neuroimaging perspective[J]. Psychiatry Clin. Psychopharmacol,2018,28(3):314-328.
29 王睿,黄树明.抑郁症发病机制研究进展[J].医学研究生学报,2014,27(12):1333-1336.
30 JiangC, SaltonSR.The role of neurotrophins in major depressive disorder [J]. Transll Neurosci,2013,4(1):46-58.
31 CattaneoA, Bocchio-ChiavettoL. Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by anti-depressant treatment [J]. Int J Neuropsychopharmacol,2010,13(1): 103-108.
32 AiM, WangJ, ChenJ, et al. Plasma brain-derived neurotrophic factor (BDNF) concentration and the BDNF Val66Met polymorphism in suicide: a prospective study in patients with depressive disorder[J]. Pharmgenomics Pers Med,2019,12: 97-106.
33 DwivediY, RizaviHS, ConleyRR, et al. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects [J]. Arch Gen Psychiatry,2003,60:804-815.
34 BanerjeeR, GhoshAK, GhoshB, et al. Decreased mRNA and protein expression of BDNF, NGF, and their receptors in the hippocampus from suicide: an analysis in human postmortem brain [J]. Clin Med Insights Pathol,2013,6(2):1-11.
35 DwivediY. Brain-derived neurotrophic factor and suicide pathogenesis [J]. Ann Med,2010,42(2): 87-96.
36 ChenB, DowlatshahiD, MacQueenGM, et al. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication [J]. Biol Psychiatry,2001,50:260-265.
37 王菁,张广芬,杨建军,等.脑源性神经营养因子在氯胺酮抗抑郁中的作用[J].医学研究生学报,2016,29(5):538-541.
38 YangY, CuiY, SangK, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. [J]. Nature,2018,554(7692):317-322.
39 DumanRS. Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide [J]. F1000Res,2018. pii:F1000 Faculty Rev-659.
40 ChenMH, LinWC, WuHJ, et al. Antisuicidal effect, BDNF Val66Met polymorphism, and low-dose ketamine infusion: Reanalysis of adjunctive ketamine study of Taiwanese patients with treatment-resistant depression (AKSTP-TRD)[J]. J Affect Disord,2019,251:162-169.
41 MorrisMC, RaoU, GarberJ. Cortisol Responses to Psychosocial Stress Predict Depression Trajectories: Social-Evaluative Threat and Prior Depressive Episodes as Moderators [J]. J Affect Disord,2012,143(1-3):223-230.
42 Yerevanian BI, FeusnerJD, KoekRJ, et al. The dexamethasone suppression test as a predictor of suicidal behavior in unipolar depression [J]. J Affect Disord,2004,83:103-108.
43 CoryellW, SchlesserM. The dexamethasome suppression test and suicide prediction [J].Am J Psychiatry,2001,158(5):748-753.
44 LindqvistD, Fernstr?mJ, GrudetC, et al. Increased plasma levels of circulating cell-free mitochondrial DNA in suicide attempters: associations with HPA-axis hyperactivity[J]. Transl Psychiatry,2016,6(12):e971.
45 AmbrusL, LindqvistD, Tr?skman-BendzL, et al. Hypothalamic-pituitary-adrenal axis hyperactivity is associated with decreased brain-derived neurotrophic factor in female suicide attempters[J]. Nord J Psychiatry,2016,70(8):575-581.
46 赵汉清,施建安,端义扬,等.抑郁症患者下丘脑-垂体-肾上腺轴功能与自杀行为[J].临床精神医学杂志,2000,10(3):132-134.
47 PitchotW, ReggersJ, PintoE, et al. Cate cholamine and HPA is dysfunction in depression: relationship with suicidal behavior [J]. Neuropsychobioloy, 2003,47(3):152-157.
48 PandeyGN, DwivediY, SridharaRaoJ, et al. Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients [J]. Neuropsychopharmacology,2002,26:216-228.
49 PandeyGN, DwivediY, PandeySC, et al. Protein kinase C in the postmortem brain of teenage suicide victims [J]. Neurosci Lett,1997,228:111-114.
50 DwivediY, RizaviHS, ShuklaPK, et al. Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits [J]. Biol Psychiatry,2004,55:234-243.
51 AnismanH, KokkinidisL, MeraliZ. Further evidence for the depressive effects of cytokines: anhedonia and neurochemical changes [J]. Brain Behav Immun,2002,16:544-556.
52 SteinerJ, BielauH, BrischR, et al. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide [J]. J Psychiatric Res,2008,42:151-157.
53 GoodwinRD, EatonWW. Asthma, suicidal ideation, and suicide attempts: findings from the Baltimore epidemiologic catchment area follow-up [J]. Am J Public Health,2005,95:717-722.
54 TonelliLH, StillerJ, RujescuD, et al. Elevated cytokine expression in the orbitofrontal cortex of victims of suicide [J]. Acta Psychiatrica Scandinavica,2008,117:198-206.
55 PandeyGN, RizaviHS, RenX, et al. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims [J]. J Psychiatr Res,2012,46:57-63.
56 WangQ, RoyB, TureckiG, et al. Role of Complex Epigenetic Switching in Tumor Necrosis Factor-α Upregulation in the Prefrontal Cortex of Suicide Subjects [J]. Am J Psychiatry,2018,175(3):262-274.
57 MensiR, MessaoudA, MhallahA, et al. The association between altered lipid profile and suicide attempt among Tunisian patients with schizophrenia[J]. Ann Gen Psychiatry,2016,15:36.

相似文献/References:

[1]丁海敬.老年食管癌患者自杀未遂1例的护理[J].医学研究与战创伤救治(原医学研究生学报),2013,15(03):312.[doi:10.3969/j.issn.1672-271X.2013.03.033]
[2]赵汉清,施建安,汪卫华.美军在伊拉克战争中自杀的预防及对我军的启示[J].医学研究与战创伤救治(原医学研究生学报),2010,12(01):91.

备注/Memo

备注/Memo:
收稿日期:2019-05-19
更新日期/Last Update: 2019-11-15