|本期目录/Table of Contents|

[1]周昊,封冰综述,王锐审校.MicroRNA调控肝细胞癌EMT 和细胞外基质重塑的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2020,22(3):277-282.[doi:10.3969/j.issn.1672-271X.2020.03.012]
　ZHOU Hao,FENG Bing reviewing,WANG Rui checking.The research progress of MicroRNA to regulate EMT and extracellular matrix remodeling in hepatocellular carcinoma[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(3):277-282.[doi:10.3969/j.issn.1672-271X.2020.03.012]
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MicroRNA调控肝细胞癌EMT 和细胞外基质重塑的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年3期
页码:
277-282
栏目:
综述
出版日期:
2020-05-15

文章信息/Info

Title:
The research progress of MicroRNA to regulate EMT and extracellular matrix remodeling in hepatocellular carcinoma
作者:
周昊; 封冰综述; 王锐审校
作者单位：210002南京，南京医科大学金陵临床医学院（东部战区总医院）肿瘤科[周昊（医学硕士研究生）、封冰、王锐]
Author(s):
ZHOU Hao; FENG Bing reviewing; WANG Rui checking
（Department of Medical Oncology, Jinling Hospital,Nanjing Medical University/General Hospital of Eastern Theater Command, PLA, Nanjing 210002，Jiangsu，China）
关键词:
肝细胞癌; 微小核糖核酸; 上皮-间质转换; 细胞外基质; 信号通路
Keywords:
hepatocellular carcinoma;  MicroRNA;  epithelial-mesenchymal transition;  extracellular matrix; signal pathway
分类号:
R735.7
DOI:
10.3969/j.issn.1672-271X.2020.03.012
文献标志码:
A
摘要:
肝细胞癌（HCC）是全球第五大侵袭性恶性肿瘤，大部分患者因为肿瘤转移而导致预后不佳，若能早期发现转移灶，并通过分子靶点有效抑制HCC的转移，可显著改善肝癌患者愈后。现已证明，上皮-间质转换（EMT）及细胞外基质重塑是肝癌细胞发生转移的重要影响因素，而miRNA可影响肝癌细胞这两种生物学行为, 但其具体机制仍有许多未知处，需要进一步探究。文章主要就miRNA通过Wnt及TGF-β通路影响肝癌细胞EMT及细胞外基质重塑的研究进展进行综述。
Abstract:
Hepatocellular carcinoma (HCC) is the fifth largest invasive malignant tumor in the world. Most patients have a poor prognosis due to tumor metastasis.If early detection of metastases and effective inhibition of HCC metastasis through molecular targets can significantly improve the prognosis of patients with HCC.It has been proved that EMT and extracellular matrix remodeling are important influencing factors for HCC cell metastasis, and miRNAs can affect these biological behaviors of HCC cells, but the specific mechanism is still unknown and needs to be further explored. This article reviews the research progress of miRNAs influencing EMT and extracellular matrix remodeling in HCC cells via Wnt and TGF-β pathways.

参考文献/References:

[1]Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65:87-108.
[2]黄晓丹,季国忠.上皮-间质转化在肿瘤侵袭转移中作用的研究进展[J].医学研究生学报，2010，23（3）:319-322.
[3]Mikami S, Katsube K, Oya M，et al. Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis [J]. Lab Investig,2011，91(10):1443-1458.
[4]李汉君, 程凯, 陈肖, 等. SOX2、TWIST及SNAIL在乳腺癌组织中的表达及临床意义[J]. 医学研究生学报, 2016,29(10):1059-1062.
[5]邱华,项灯,时军，等.microRNAs调控上皮间质转化影响胆管癌侵袭转移的研究进展[J].医学研究生学报，2017，30（6）:665-668.
[6]Sato Y, Harada K, Itatsu K, et al.Epithelial-mesenchymal transition induced by transforming growth factor-β1/Snail activation aggravates invasive growth of cholangiocarcinoma[J].Am J Pathol, 2010, 177 (1):141-152.
[7]杨鑫苗, 张永强. miRNA在实体肿瘤诊断及治疗中的研究进展[J]. 癌症进展, 2019,17(10):1117-1119.
[8]Song Y, Wang F, Huang Q, et al.MicroRNAs Contribute to Hepatocellular Carcinoma[J].Mini Rev Med Chem, 2015, 15(6):459-466.
[9]刘大毛, 李勇. 经典Wnt信号通路与原发性肝癌的研究进展[J]. 南昌大学学报（医学版）, 2014, 54(12):100-103.
[10]Liu P, Chen B, Gu Y,et al. PNMA1, regulated by miR-33a-5p, promotes proliferation and EMT in hepatocellular carcinoma by activating the Wnt/β-catenin pathway[J]. Biomed Pharmacother,2018，108（13）:492-499.
[11]Ye Y, Long X, Zhang L, et al. NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/β-catenin signaling pathway in hepatocellular carcinoma[J]. Oncotarget, 2016, 7(43):70303-70322.
[12]阙克婷. microRNA-766-3p通过靶向Wnt3a抑制原发性肝癌的发展[D].重庆医科大学，2019.
[13]Quan H, Li B,Yang J, et al.MicroRNA-504 functions as a tumor suppressor in hepatocellular carcinoma through inhibiting Frizzled-7-mediated-Wnt/β-catenin signaling[J]. Biomed Pharmacother,2018, 107（8）: 754-762.
[14]Wu W, Dang S, Feng Q, et al. MicroRNA-542-3p inhibits the growth of hepatocellular carcinoma cells by targeting FZD7/Wnt signaling pathway[J].Biochem Biophys Res Commun, 2016, 482(1):100.
[15]Zhang T, Liu W, Meng W, et al. Downregulation of miR-542-3p promotes cancer metastasis through activating TGF-β/Smad signaling in hepatocellular carcinoma[J]. Onco Targets Ther, 2018, 11:1929-1939.
[16]Wang Y, Sun L, Wang L, et al. Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/β-catenin signal pathway in hepatocellular carcinoma[J]. Cell Death Dis, 2018,9（9）:851.
[17]Zhu Q, Lu G, Luo Z, et al. CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis[J]. Biochem Biophys Res Commun, 2018, 497(2):626.
[18]Yarui L, Dan G, Yan Z, et al. Long non-coding RNA SNHG5 promotes human hepatocellular carcinoma progression by regulating miR-26a-5p/GSK3β signal pathway[J].Cell Death Dis, 2018, 9(9):888.
[19]Cao L, Xie B, Yang X, et al. MiR-324-5p Suppresses Hepatocellular Carcinoma Cell Invasion by Counteracting ECM Degradation through Post-Transcriptionally Downregulating ETS1 and SP1[J].PLoS One, 2015, 10(7):eD133074.
[20]周凯, 周文泉. Wnt信号通路抑制因子SFRPs在肿瘤发生发展中的研究进展[J]. 医学研究生学报, 2012,25(9):997-1001.
[21]Chen Y, Zhang F, Zhao Y, et al. Obesity-associated miR-27a upregulation promotes hepatocellular carcinoma metastasis through suppressing SFRP1[J]. Onco Targets Ther, 2018, 11:3281-3292.
[22]Cao MQ, You AB, Zhu XD, et al. miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a[J].J Hematol Oncol, 2018, 11(1):12.
[23]Guo Y, Chen L, Sun C, et al. MicroRNA-500a promotes migration and invasion in hepatocellular carcinoma by activating the Wnt/β-catenin signaling pathway[J]. Biomed Pharmacother, 2017, 2（91）:13-20.
[24]Cui H, Song R, Wu J, et al. MicroRNA-337 regulates the PI3K/AKT and Wnt/2-catenin signaling pathways to inhibit hepatocellular carcinoma progression by targeting high-mobility group AT-hook 2[J]. Am J Cancer Res, 2018, 8(3):405-421.
[25]Miyazono K, Ehata S, Koinuma D. Tumor-promoting functions of transforming growth factor-β in progression of cancer[J]. Ups J Med Sci, 2012, 117(2):143-152.
[26]Yu Q, Xiang L, Yin L, et al. Loss-of-function of miR-142 by hypermethylation promotes TGF-β-mediated tumour growth and metastasis in hepatocellular carcinoma[J]. Cell Prolif, 2017,5（50）:405-421.
[27]Chen Y, Xu Q, Guo F, et al. MicroRNA-302d downregulates TGFBR2 expression and promotes hepatocellular carcinoma growth and invasion[J]. Exp Ther Med, 2016, 8（13）: 681-687.
[28]Jiang X,Xiang G,Wang Y,et al. MicroRNA-590-5p regulates proliferation and invasion in human hepatocellular carcinoma cells by targeting TGF-β RII[J].Mol Cells, 2012, 33(6):545-551.
[29]Yu Q, Xiang L, Yin L, et al. Loss-of-function of miR-142 by hypermethylation promotes TGF-β-mediated tumour growth and metastasis in hepatocellular carcinoma[J].Cell Prolif, 2017,9（50）:405-421.
[30]Zhou J, Xiang L, Yin L, et al. MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4[J]. Hepatology, 2015, 62(3）:801-815.
[31]Sun L, Guo Z,Sun J, et al. MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway[J]. Biomed Pharmacother, 2018,13（107）:168-176.
[32]Wang JY, Fang M, Boye A, et al. Interaction of microRNA-21/145 and Smad3 domain-specific phosphorylation in hepatocellular carcinoma[J]. Oncotarget, 2017, 8(49):84958-84973.
[33]Gregory PA, Bracken CP, Bert AG, et al. MicroRNAs as regulators of epithelial-mesenchymal transition[J]. Cell Cycle, 2008, 7(20):3112-3117.
[34]Zhou SJ, Liu FY, Zhang AH, et al. MicroRNA-199b-5p attenuates TGF-β1-induced epithelial-mesenchymal transition in hepatocellular carcinoma[J]. Brit J Cancer, 2017,3（8）:233-244.
[35]Meng Z,Xiang L, Yin L,et al.miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice[J]. Hepatology, 2010, 52(6):2148-2157.
[36]Sandbothe M, Buurman R, Reich N, et al. The microRNA-449 family inhibits TGF-β-mediated liver cancer cell migration by targeting, SOX4[J].J Hepatol, 2017, 66(5):1012-1021.
[37]Wong CC, Tse AP, Huang YP,et al. Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma[J]. Hepatology, 2014,60(5):1645-1658.
[38]Zhou SL, Hu ZQ, Zhou ZJ, et al. miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis[J]. Hepatology, 2016,63（8）:1560-1575.

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备注/Memo

备注/Memo:
基金项目：江苏省科教强卫工程青年医学人才项目（QNRC2016886）
更新日期/Last Update: 2020-05-15