|本期目录/Table of Contents|

[1]张鹏,聂时南.氧化亚氮致神经功能损害研究进展[J].医学研究与战创伤救治(原医学研究生学报),2021,23(02):180-184.[doi:10.3969/j.issn.1672-271X.2021.02.015]
　ZHANG Peng,NIE Shi-nan.Research progress on neurological damage caused by nitrous oxide (N2O)[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(02):180-184.[doi:10.3969/j.issn.1672-271X.2021.02.015]
点击复制

氧化亚氮致神经功能损害研究进展()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年02期
页码:
180-184
栏目:
综述
出版日期:
2021-03-22

文章信息/Info

Title:
Research progress on neurological damage caused by nitrous oxide (N2O)
作者:
张鹏; 聂时南
210002南京，南京大学医学院附属金陵医院（东部战区总医院）急诊医学科（张鹏、聂时南）
Author(s):
ZHANG Peng ;  NIE Shi-nan
(Department of Emergency, Jinling Hospital, Nanjing University School of Medicine / General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China)
关键词:
氧化亚氮; 维生素B12; 神经系统损害
Keywords:
nitrous oxide;  vitamin B12;  nervous system damage
分类号:
R743
DOI:
10.3969/j.issn.1672-271X.2021.02.015
文献标志码:
B
摘要:
氧化亚氮（N2O）是一种吸入性麻醉药，具有短暂致欣快和抗焦虑作用，近几年以毒品替代品角色风靡于娱乐场所的年轻群体之间。临床上N2O滥用致神经系统损伤的相关病例逐年递增。文章主要就N2O中毒致神经功能损害致病机制、中毒剂量、临床表现、辅助检查、诊断治疗等进行综述。
Abstract:
Nitrous oxide (N2O), commonly known as "laughing gas", is an inhaled anesthetic with transient euphoric and anxiolytic effects. In recent years, the role of drug substitutes has become popular among young people in entertainment venues. Clinically, N2O abuse causes neurological damage relevant cases to increase year by year. This article reviews the pathogenic mechanism, poisoning dose, clinical manifestations, auxiliary examination, diagnosis and treatment of neurological damage caused by N2O poisoning.

参考文献/References:

[1]Nagele P, Zorumski CF, Conway C. Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts[J]. J Clin Psychopharmacol, 2018, 38(2): 144-148.
[2]van Amsterdam J, Nabben T, van den Brink W. Recreational nitrous oxide use: Prevalence and risks[J]. Regul Toxicol Pharmacol, 2015, 73(3): 790-796.
[3]Oussalah A, Julien M, Levy J, et al. Global Burden Related to Nitrous Oxide Exposure in Medical and Recreational Settings: A Systematic Review and Individual Patient Data Meta-Analysis[J]. J Clin Med, 2019,8(4):551.
[4]Amess JA, Burman JF, Rees GM, et al. Megaloblastic haemopoiesis in patients receiving nitrous oxide[J]. Lancet (London, England), 1978, 2(8085): 339-342.
[5]胡斌. 维生素B12与糖尿病的相关性研究进展[J]. 医学研究生学报, 2019, 32(3):303-306.
[6]Guéant JL, Caillerez-Fofou M, Battaglia-Hsu S, et al. Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase[J]. Biochimie, 2013, 95(5): 1033-1040.
[7]Ghemrawi R, Pooya S, Lorentz S, et al. Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1[J]. Cell Death Dis, 2013, 4: e553.
[8]Bicakci Z. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis[J]. Medicine, 2015, 94(9): e584.
[9]Oussalah A, Julien M, Levy J, et al. Global Burden Related to Nitrous Oxide Exposure in Medical and Recreational Settings: A Systematic Review and Individual Patient Data Meta-Analysis[J]. J Clin Med, 2019, 8(4):551.
[10]Cui J, Wang Y, Zhang H, et al. Isolated subacute combined degeneration in late-onset cobalamin C deficiency in children: Two case reports and literature review[J]. Medicine, 2019, 98(39): e17334.
[11]Veber D, Mutti E, Galmozzi E, et al. Increased levels of the CD40:CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy[J].J Neuroimmunol, 2006, 176(1-2): 24-33.
[12]Scalabrino G, Veber D, Tredici G. Relationships between cobalamin, epidermal growth factor, and normal prions in the myelin maintenance of central nervous system[J]. Int J Biochem Cell Biol, 2014, 55: 232-241.
[13]Misra UK, Singh SK, Kalita J, et al. Astrocyte activation following nitrous oxide exposure is related to oxidative stress and glutamate excitotoxicity[J]. Brain Res, 2020, 1730: 146645.
[14]Fleming AM, Ding Y, Burrows CJ. Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair[J]. Proc Natl Acad Sci USA, 2017, 114(10): 2604-2609.
[15]Vodicka P, Musak L, Fiorito G, et al. DNA and chromosomal damage in medical workers exposed to anaesthetic gases assessed by the lymphocyte cytokinesis-block micronucleus (CBMN) assay. A critical review[J].Mutat Res, 2016, 770(Pt A): 26-34.
[16]Saito H, Kato R, Hashimoto T, et al. Influence of nitrous oxide on granule cell migration in the dentate gyrus of the neonatal rat[J]. Biomed Res, 2018, 39(1): 39-45.
[17]Gürsoy AE, Koluksa M, Babacan-Yldz G, et al. Subacute Combined Degeneration of the Spinal Cord due to Different Etiologies and Improvement of MRI Findings[J]. Case Rep Neurol Med, 2013, 2013: 159649.
[18]王云云. 滥用一氧化二氮致长节段脊髓病变的临床分析[J]. 北京大学学报（医学版）, 2019, 51 (2):303-306.
[19]Lan SY, Kuo CY, Chou CC, et al. Recreational nitrous oxide abuse related subacute combined degeneration of the spinal cord in adolescents - A case series and literature review[J]. Brain Dev, 2019, 41(5): 428-435.
[20]Fang X, Li W, Gao H, et al. Skin hyperpigmentation: a rare presenting symptom of nitrous oxide abuse[J].Clin Toxicol (Phila), 2019: 1-6.
[21]Ernst LD, Brock K, Barraza LH, et al. Longitudinally Extensive Nitrous Oxide Myelopathy With Novel Radiographic Features[J].JAMA Neurol, 2015, 72(11): 1370-1371.
[22]Li HT, Chu CC, Chang KH, et al. Clinical and electrodiagnostic characteristics of nitrous oxide-induced neuropathy in Taiwan[J]. Clin Neurophysiol, 2016, 127(10): 3288-3293.
[23]Stockton L, Simonsen C, Seago S. Nitrous oxide-induced vitamin B12 deficiency[J]. Proc (Bayl Univ Med Cent), 2017, 30(2): 171-172.
[24]Algahtani H, Shirah B, Abdelghaffar N, et al. Nitrous oxide recreational abuse presenting with myeloneuropathy and mimicking Guillain-Barre syndrome[J].Intractable Rare Dis Res, 2020, 9(1): 54-57.
[25]Johnson K, Mikhail P, Kim MG, et al. Recreational nitrous oxide-associated neurotoxicity[J]. J Neurol Neurosurg Psychiatry, 2018, 89(8): 897-898.
[26]Keddie S, Adams A, Kelso AC, et al. No laughing matter: subacute degeneration of the spinal cord due to nitrous oxide inhalation[J]. J Neurol, 2018, 265(5): 1089-1095.
[27]Luo D, Xu J, Hu L, et al. Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by NO for recreational use: a case report[J]. Neuropsychiatr Dis Treat, 2018, 14: 1963-1967.

相似文献/References:

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2021-03-22