|本期目录/Table of Contents|

[1]马遥,刘南海,翁燕红,等.红细胞体积异质性与急性脑梗死患者中枢神经元细胞损伤的关系[J].医学研究与战创伤救治(原医学研究生学报),2021,23(05):484-488.[doi:10.3969/j.issn.1672-271X.2021.05.008]
　MA Yao,LIU Nan-hai,WENG Yan-hong,et al.Relationship between red blood cell volume heterogeneity and central neurons injury in patients with acute ischemic stroke[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(05):484-488.[doi:10.3969/j.issn.1672-271X.2021.05.008]
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红细胞体积异质性与急性脑梗死患者中枢神经元细胞损伤的关系()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年05
页码:
484-488
栏目:
临床研究
出版日期:
2021-09-20

文章信息/Info

Title:
Relationship between red blood cell volume heterogeneity and central neurons injury in patients with acute ischemic stroke
作者:
马遥; 刘南海; 翁燕红; 张莉; 刘洋; 朱浩轩; 熊文娟; 欧阳晓春
作者单位：330002南昌，解放军联勤保障部队第九○八医院神经内科（马遥、翁燕红、张莉、刘洋、朱浩轩、熊文娟、欧阳晓春）；341000赣州，赣南医学院第一附属医院神经内科（刘南海）
Author(s):
MA Yao1;  LIU Nan-hai 2; WENG Yan-hong1; ZHANG Li1;  LIU Yang1;  ZHU Hao-xuan1;  XIONG Wen-juan1;  OUYANG Xiao-chun1
（1.Department of Neurology, No.908 Hospital of the People’s Liberation Army Joint Logistics Support Force, Nanchang 330002, Jiangxi, China；2.Department of Neurology, First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi, China）
关键词:
急性脑梗死; 红细胞分布宽度; 神经元特异性烯醇化酶; 多因素分析
Keywords:
acute ischemic stroke; red blood cell distribution width; neuron specific enolase; multivariate analysis
分类号:
R743
DOI:
10.3969/j.issn.1672-271X.2021.05.008
文献标志码:
A
摘要:
目的探讨急性脑梗死（AIS）患者红细胞体积异质性与反映中枢神经元细胞损伤的神经元特异性烯醇化酶(NSE)水平的关系及其临床意义。方法回顾性分析2018年1月至2020年12月解放军联勤保障部队第九○八医院及赣南医学院第一附属医院神经内科确诊的300例AIS住院患者的临床与生化资料。根据入院时血清NSE水平将患者分为NSE正常组（239例）与偏高组（61例）。比较2组患者的生化资料，分析反应外周血红细胞体积异质性的指标-红细胞分布宽度(RDW) 与NSE水平的相关性。采用多因素线性回归分析RDW对血清NSE水平的影响。结果血清NSE正常组与偏高组RDW值分别为（41.63±2.44）%与（44.00±4.12）%，差异有统计学意义（P<0.01）；2组患者间性别、高血压、糖尿病、房颤、红细胞数量、血红蛋白、红细胞平均体积、中性细胞数、血小板、总胆固醇、三酰甘油、低密度脂蛋白、谷丙转氨酶、肌酐、尿酸、空腹血糖、CEA、AFP及非小细胞肺癌相关抗原等指标比较差异无统计学意义（P>0.05）；2组间年龄、冠心病、RDW、白细胞及NSE等指标比较差异有统计学意义（P<0.05）；RDW值低、中、高三等份组患者NSE水平逐渐升高，3组间总体比较差异有统计学意义（P<0.01）；RDW与NSE水平呈正相关(r=0.347，95%CI: 0.243~0.443, P<0.01)。调整混杂因素前RDW对NSE水平升高的风险 [β（95%CI）P]为0.38 (0.26~0.49) <0.001，调整因素后为0.33 (0.20~0.46) <0.001。结论AIS患者外周血RDW值与血清NSE水平成正相关，对探讨红细胞变形功能与中枢神经元细胞损伤的关系有一定的临床价值。
Abstract:
ObjectiveTo explore the relationship between red blood cell volume heterogeneity and the level of neurogenic-specific enolase(NSE) which reflecting central neurons injury in patients with acute ischemic stroke（AIS）.MethodsClinical and biochemical data of 300 AIS patients were retrospectively analyzed in departments of neurology in 908 Hospital of the People’s Liberation Army Joint Logistics Support Force and the First Affiliated Hospital of Gannan Medical College from January 2018 to December2020. According to the NSE level on admission, include patients were subdivided into the normal NSE group (239 cases) and the high NSE group (61 cases). Clinical dates were compared between the two groups, and the correlation between red blood cell distribution width (RDW) with NSE level was analyzed, and multivariate linear regression analysis was utilized to investigate the relationship between RDW and NSE.ResultsThe RDW in normal NSE group and high NSE group were (41.63±2.44) % and (44±4.12) %, respectively, and the difference between the two groups was statistically significant (P<0.01). Between the two groups, there was no significant difference in sex, hypertension, diabetes, atrial fibrillation, number of red blood cell (RBC), hemoglobin, mean RBC volume, number of neutrophils, platelet, total cholesterol, triglyceride, low density lipoprotein, glutamic-pyruvic transaminase, creatinine, uric acid, fasting blood glucose, CEA, AFP and non-small cell lung cancer-related antigens (all P>0.05), and there were significant differences in age, coronary heart disease, RDW, white blood cell and NSE between the two groups (P<0.05). The NSE level of patients increased gradually in the low, medium and high RDW groups, and there was a statistical difference among the three groups (P<0.01). RDW was positively correlated with NSE level (r=0.275, 95%CI: 0.187-0.359, P<0.01). The beta coefficients (95%CI) between RDW and serum NSE levels was 0.38 (0.26-0.49, P<0.001) and 0.33 (0.20-0.46, P<0.001), respectively, in AIS patients before and after adjusting for potential confounding.ConclusionThe RDW value of peripheral blood and NSE level in AIS patients are positively correlated, which is of certain clinical value to explore the relationship between the deformation function of red blood cells and damage of central nervous cells.

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更新日期/Last Update: 2021-10-11