|本期目录/Table of Contents|

[1]蔡少甫,郑庆亦,郭毅斌,等.严重烧伤患者血脂变化与感染关系的研究[J].医学研究与战创伤救治(原医学研究生学报),2008,10(04):274.
　CAI Shao-fu,ZHENG Qing-yi,GUO Yi-bin,et al.The study of serum lipids changes in patients with severe burns and its relations with infectious complications[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(04):274.
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严重烧伤患者血脂变化与感染关系的研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第10卷
期数:
2008年04期
页码:
274
栏目:
出版日期:
2008-07-20

文章信息/Info

Title:
The study of serum lipids changes in patients with severe burns and its relations with infectious complications
文章编号:
1672-271X(2008)04-0274-03
作者:
蔡少甫; 郑庆亦; 郭毅斌; 陈锦河; 郑健生; 张阳根
解放军第175医院南京军区烧伤整形研究所，福建漳州363000
Author(s):
CAI Shao-fu;  ZHENG Qing-yi;  GUO Yi-bin;  CHEN Jin-he;  ZHENG Jian-sheng;  ZHANG Yang-gen
Department of Burns and Plastic Surgery, the 175th Hospital of PLA, Zhangzhou 363000, Fujian, China
关键词:
烧伤; 感染; 脂蛋白类; 高密度脂蛋白
Keywords:
Burns; Infection; Lipoproteins; HDL
分类号:
R644
DOI:
-
文献标志码:
A
摘要:
目的探讨严重烧伤患者血脂变化特点与感染并发症的关系。方法40例伤后24 h内入院的18~59岁严重热力烧伤患者，于入院时和伤后1、2、3、5、7、14、21 d空腹采血样本，检测血清总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A1(apoA1)、甘油三酯(TG)水平，并监测感染并发症和预后情况。以40例健康体检者作为对照组。结果40例患者中有21例发生感染37例次，感染发生率52.5%。与对照组比较，患者伤后1 d 脂蛋白已明显降低(Ｐ＜0.01)，伤后3~7 d TC、HDL、apoA1、LDL降至最低水平，其中以HDL降幅最大。在伤后2~21 d，感染者的HDL、apoA1水平明显低于非感染者(P＜0.01)。结论患者烧伤后TC、HDL、apoA1、LDL降低，HDL水平降低与感染有关。
Abstract:
ObjectiveTo investigate the changes of serum lipids in patients with severe burns and its relations with infectious complications.Methods Forty patients with thermal severe injuries aged from 18 to 59 years admitted within 24 hours, and blood samples were drawn on admission and postburn day 1,2,3,5,7,14 and 21.Serum total cholesterol (TC), high-density lipoproteins (HDL),low-density lipoproteins (LDL), apolipoprotein A1(apoA1),and triglyceride (TG) were measured in all patients and compared with those of 40 volunteers.The infectious complications and outcome were monitored.ResultsIn 40 patients, a total of 37 identifiable infection episodes occurred in 21 patients (52.5%). The concentrations of serum lipoproteins in patients decreased significantly on day 1, lower than those of the controls (P<0.01), and reached a nadir in day 3 to day 7, especially HDL. From day 2 to day 21, HDL and apoA1 levels in infection patients were lower than those in non-infection patients (P<0.01).ConclusionThe concentrations of serum TC, HDL, apoA1,and LDL decreased in severe burn patients,and lower HDL levels might be related to the infectious complications.

参考文献/References:

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备注/Memo

备注/Memo:
全军“十一五”计划项目基金资助(06MA107)
更新日期/Last Update: 2013-11-22