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[1]潘雪飞,杜 斌,范 群,等.综合分析药物性肝损伤4 076例[J].医学研究与战创伤救治(原医学研究生学报),2009,11(06):505-507.
　PAN Xue-fei,DU Bin,FAN Qun,et al.The statistic analysis of the 4 076 patients with drug induced liver injury[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(06):505-507.
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综合分析药物性肝损伤4 076例()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第11卷
期数:
2009年06期
页码:
505-507
栏目:
出版日期:
2009-11-20

文章信息/Info

Title:
The statistic analysis of the 4 076 patients with drug induced liver injury
文章编号:
1672-271X(2009)06-0505-03
作者:
潘雪飞1; 杜 斌2; 范 群3; 陈小凤1; 张长法1
1.解放军第454医院，江苏南京 210002;2.南京中医药大学，江苏南京 210029;3.江苏职工医科大学，江苏南京 210029
Author(s):
PAN Xue-fei1; DU Bin2; FAN Qun3; CHEN Xiao-Feng1; ZHANG Chang-fa1
1.The 454th Hospital of PLA, Nanjing 210002,Jiangsu,China;2.Nanjing University of Traditional Chinese Medicine，Nanjing 210029，Jiangsu,China;3.Nanjing Chest Hospital of Jiangsu,Nanjing 210029，Jiangsu,China
关键词:
药物性肝损伤; 中草药; 抗结核药; 抗生素
Keywords:
Drug induced liver injury;  Chinese herb;  Antituberculotic drugs;  Antibiotics
分类号:
R575.1
DOI:
-
文献标志码:
A
摘要:
目的 分析引起药物性肝损伤的原因、临床分型和预后。方法 检索药物性肝损伤的相关文献并进行统计分析。结果 本组资料显示药物性肝损伤以中年人居多，＞60岁者占20.4%，病死率约3.1%;引起肝损伤的前三位药物分别为中草药、抗结核药及抗生素，损伤类型以肝细胞损伤型居多，占54.2%；我国南北方未见明显地域差异。结论 必须对患者加强引导，要遵照医嘱用药；对医务人员加强培训，注意鉴别诊断，及时报告，妥善处置。
Abstract:
Objective To analysis the causes, clinical classification and prognosis of drug induced liver injury. Methods To analysis the retrieval documentary data of DILI using statistics method. Results In China, the middle age of the patients who had DILI with no difference in gender. 20.4% of them were older than 60 years. The first three causes of DILI were the use of Chinese herb, antituberculotic drugs, and antibiotics. There was no geographical difference. The most common hepatic injury type was hepatocyte injury, which account for 54.2%, and the fatality rate was about 3.1%. Conclusion It is necessary to educate and guide the patients to take medicine complying with doctor's advice. The medical staffs have to pay more attention to the diagnosis, report without delay, and deal with drug induced liver injury correctly.

参考文献/References:

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更新日期/Last Update: 2013-11-20