[1]卢 杰,祁 宾,宗 林,等.丙泊酚联合喷他佐辛用于人工流产术的效果观察[J].医学研究与战创伤救治(原医学研究生学报),2011,13(01):31-33.
　LU Jie,QI Bin,ZONG Lin,et al.The effects of propofol in combination with small doses of pentazocine in painless artificial abortion[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(01):31-33.
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丙泊酚联合喷他佐辛用于人工流产术的效果观察()

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年01期
页码:
31-33
栏目:
出版日期:
2011-01-20

文章信息/Info

Title:
The effects of propofol in combination with small doses of pentazocine in painless artificial abortion
文章编号:
1672-271X(2011)01-0031-03
作者:
卢 杰1; 祁 宾2; 宗 林1; 张应祥1; 王玉秀1
223001 江苏淮安，1.解放军82医院麻醉科； 2.淮安市第一人民医院麻醉科
Author(s):
LU Jie1;  QI Bin2;  ZONG Lin1;  ZHANG Ying-xiang1;  WANG Yu-xiu1
1. Department of Anesthesiology, 82 Hospital of PLA, Huai’an, Jiangsu 223001, China；2. Department of Anesthesiology, the First Hospital of Huai’an, Huaii’an, Jiangsu 223001, China
关键词:
静脉麻醉; 丙泊酚; 芬太尼; 喷他佐辛; 无痛人工流产
Keywords:
intravenous nesthesia;  propofol; fentanyl; pentazocine; painless artificial abortion
分类号:
R614.2+4
DOI:
-
文献标志码:
A
摘要:
目的 探讨丙泊酚联合小剂量喷他佐辛用于无痛人工流产术的可行性及其优点。 方法 160例ASAⅠ级早期妊娠患者随机分为四组，每组40例。 A组:丙泊酚2.5 mg/kg； B组:芬太尼0.001 mg/kg、丙泊酚2 mg/kg；C组:喷他佐辛0.3 mg/kg、丙泊酚2 mg/kg；D组:喷他佐辛0.6 mg/kg、丙泊酚2 mg/kg。术中出现肢体扭动者酌情追加丙泊酚30~40 mg。观察比较麻醉前后呼吸循环变化、麻醉镇痛效果、术后恢复情况及不良反应等。结果 四组患者都成功完成手术。各组用药后均有明显循环抑制(P<0.05)， 以A组最为显著(P<0.01)。呼吸抑制发生率B组显著高于其他组(P<0.01)。术中镇痛不全和术后腹痛发生率A组显著高于其他各组(P<0.05)；苏醒及离院时间D组显著长于A、B、C组(P<0.01)。结论 丙泊酚联合小剂量喷他佐辛(0.3 mg/kg)能较好地满足无痛人工流产手术麻醉需要，并能减少单用丙泊酚时镇痛不全、严重循环抑制和加用芬太尼时明显的呼吸抑制，值得推广应用于各类无痛诊疗技术。
Abstract:
Objective To explore the feasibility of propofol in combination with small doses of pentazocine in painless abortion. Methods 160 early-pregnant women with ASAⅠwere randomly divided into four groups (40 patients each group). Patients in group A were given intravenous propofol; Patients in group B were given fentanyl 0.001 mg/kg followed by propofol intravenously; Patients in group C and D were given 0.3 mg/kg or 0.6 mg/kg pentazocine respectively before intravenous propofol. The initial dose of propofol in group A was 2.5 mg/kg and 2 mg/kg in other groups, and additional doses will be applied when body motion occurred. The changes of respiratory and circulatory function, anesthesia and analgesia effects, postoperative recovery profile, and side-effects were observed. Results The operations were successful in all the patients. All patients showed circulatory depression after anesthesia, and the patients in group A were the severest (P<0.05). Among all patients in four groups, the respiratory depression incidence rates of patients in group B was the highest (P<0.01), the intraoperative insufficient analgesia and postoperative abdominal pain incidence rates of patients in group A was the most significant (P<0.05). In addition, the awake time and departure time of patients in group D was the longest (P<0.05). Conclusion Propofol in combination with small doses of pentazocine (0.3 mg/kg) could decrease the incidence of insufficient analgesia compared with using propofol alone and alleviate fentanyl induced respiratory depression in painless artificial abortion, which is the suitable anesthetic compatibility.

参考文献/References:

[1]孙惠敏．无痛人工流产术中异丙酚的配伍方案[J］．东南国防医药，2006，8(4):315-318．
[2］徐 涛，秦秀朵，王秀梅．丙泊酚和氧化亚氮及利多卡因用于人工流产中镇痛疗效观察[J］．东南国防医药，2005，7(6):439-440．
[3］庄秀丽．不同药物配伍在早孕无痛人流术中的临床效果分析[J］．海南医学，2007，18(2):31-32．
[4］庄心良，曾因明，陈伯銮．现代麻醉学[M］．3版．北京:人民卫生出版社，2004:520-527．
[5］徐建国．慢性疼痛的药物治疗进展[J］．医学研究生学报，2007，20(2):113-119.
[6］Bowdle T A．Adverse effects of opioid agonists-antagonists in anaesthesia[J］．Drug Saf，1998，19(3):173-189.
[7］闫 焱，佘守章，许立新，等．喷他佐辛用于全麻气管插管诱导的可行性研究[J］．河北医学，2008，14(7):808-811.
[8］邱小弟，佘守章，黄焕森．喷他佐辛临床镇痛的应用研究进展[J］．广东医学，2010，31(10):1218-1220.
[9］马进文．喷他佐辛与吗啡在食管癌术后自控镇痛的效果比较[J］．中国民康医学，2008，20(20):2364.
[10］赵国栋，孙来宝，黄文起．喷他佐辛的药代动力学及药效学研究[J］．广东医学，2010，31(10):1216-1218.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2011-01-20