|本期目录/Table of Contents|

[1]冯青青,樊拖迎,李春安,等.乙型肝炎后肝硬化患者胆结石形成的机制探讨[J].医学研究与战创伤救治(原医学研究生学报),2011,13(03):217-218.
　FENG Qing-qing,FAN Tuo-ying,LI Chun-an,et al.Mechanism of gallstone formation in patients with cirrhosis after hepatitis B[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(03):217-218.
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乙型肝炎后肝硬化患者胆结石形成的机制探讨()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年03期
页码:
217-218
栏目:
出版日期:
2011-05-20

文章信息/Info

Title:
Mechanism of gallstone formation in patients with cirrhosis after hepatitis B
文章编号:
1672-271X(2011)03-0217-02
作者:
冯青青; 樊拖迎; 李春安; 幸 军
330002 江西南昌，解放军94医院消化科
Author(s):
FENG Qing-qing;  FAN Tuo-ying;  LI Chun-an;  XING Jun.
Department of Digestive Disease,94 Hospital of PLA, Nanchang, Jiangxi 330002, China
关键词:
肝硬化; 乙型肝炎; 胆结石; 雌二醇; 高密度脂蛋白胆固醇; 胆红素
Keywords:
cirrhosis;  hepatitis B;  gallstones;  estradiol;  high-density lipoprotein cholesterol;  bilirubin
分类号:
R575.62
DOI:
-
文献标志码:
A
摘要:
目的 探讨乙型肝炎后肝硬化(简称肝硬化)患者胆结石之患病率以及血清雌二醇(E2)、高密度脂蛋白胆固醇(HDL-C)和总胆红素(TBil)在胆结石形成机制中的作用。方法 分析住院男性肝硬化患者胆结石的患病率。测定肝硬化胆结石患者(68例)和无胆结石患者(120例)血清E2、HDL-C、TBil以及胆囊壁厚度和胆囊横径水平变化，并进行相关分析。结果 肝硬化A级患者胆结石患病率为7.9%(3/38)、B级27.5%(22/80)、C级61.4%(43/70)。肝硬化胆结石组血清E2、TBil、胆囊厚度和胆囊横径均明显高于肝硬化无胆结石组，而HDL-C低于无胆石组(P<0.01)。肝硬化胆结石组血清E2水平与TBil和胆囊横径、胆囊壁厚度明显正相关，与高密度脂蛋白胆固醇呈负相关(P<0.05)。结论 男性肝硬化患者胆结石患病率与病情程度密切相关；肝硬化患者血清E2、HDL-C和TBil水平变化在胆结石形成中发挥重要作用。
Abstract:
Objective To explore the incidence of gallstones in patients with the cirrhosis after hepatitis B and the role of serum estradiol (E2), high-density lipoprotein cholesterol (HDL-C), and bilirubin in gallstone formation. Methods The incidence of gallstones in male patients at the hospital with post-hepatitis B cirrhosis was analyzed. The serum level of E2, HDL-C,TBil and the thickness of bladder wall and transverse diameter were measured in 68 cases with cirrhosis and in 120 cases without cirrhosis. Results The incidences of gallstones in patients with A, B and C grade of cirrhosis after hepatitis B was 10.4%, 28% and 61.4% accordingly. The serum levels of E2, TBil, gallbladder thickness and diameter of the gallbladder in patients with post-hepatitis B cirrhosis gallstones were significantly higher than those in posthepatitis cirrhosis without gallstones group. The HDL-C was lower than those without gallstone group (P<0.01). In gallstones after hepatitis B cirrhosis group, levels of E2 was positively correlated with levels of TBil, gallbladder diameter and gallbladder wall thickness and was negatively correlated with levels of HDL-C (P<0.05).Conclusion The incidence of gallstones in male patients with cirrhosis after hepatitis B was significantly elevated and the level of E2, HDL-C, and TBil plays an important role in the formation of gallstone.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2011-05-20