|本期目录/Table of Contents|

[1]樊 有,姜 静,蒋德升,等.96株儿童肺炎链球菌耐药情况分析[J].医学研究与战创伤救治(原医学研究生学报),2011,13(04):299-301.
　FAN You,JIANG Jing,JIANG De-sheng,et al.Resistance of 96 strains of streptococcus pneumoniae in children[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(04):299-301.
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96株儿童肺炎链球菌耐药情况分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年04期
页码:
299-301
栏目:
出版日期:
2011-07-20

文章信息/Info

Title:
Resistance of 96 strains of streptococcus pneumoniae in children
文章编号:
1672-271X(2011)04-0299-03
作者:
樊 有1; 姜 静1; 蒋德升1; 尚 宁1; 施 毅2
1.210002 江苏南京，解放军454医院呼吸科；2.210002 江苏南京，南京军区南京总医院呼吸科
Author(s):
FAN You1; JIANG Jing1; JIANG De-sheng1; SHANG Ning1; SHI Yi2.
1.Department of Respiratory Disease,454 Hospital of PLA,Nanjing，Jiangsu 210002，China;2.Department of Respiratory Disease,Nanjing General Hospital of Nanjing Military Command,Nanjing，Jiangsu 210002，China
关键词:
肺炎链球菌; 耐药率; 儿童
Keywords:
streptococcus pneumoniae;  resistance;  children
分类号:
R378.14
DOI:
-
文献标志码:
A
摘要:
目的 了解南京地区儿童感染肺炎链球菌对常用抗菌药物的耐药性。方法 琼脂稀释法测定96株肺炎链球菌对14种抗菌药物最低抑菌浓度。结果 96株肺炎链球菌中，耐青霉素肺炎链球菌(penicillin resist streptococcus pneumoniae，PRSP)最小抑菌浓度(minimal inhibitory concentration，MIC)≥2 mg/L的检出率为65.6%；头孢呋辛、头孢噻肟、阿莫西林、头孢曲松的耐药率依次为87.5%、29.2%、8.3%和4.2%；红霉素、四环素、阿奇霉素和克林霉素耐药率分别为96.9%、95.8%、95.8%、94.8%；万古霉素、替加环素、利奈唑胺均敏感。结论 南京地区儿童肺炎链球菌对青霉素、红霉素、阿奇霉素、克林霉素和四环素、头孢呋辛等抗生素耐药性高，应注意合理选择用药。
Abstract:
Objective To investigate antibiotic resistance of streptococcus pneumoniae to children in Nanjing.Methods Totally 96 strains of streptococcus pneumoniae were collected to test the MICs of various antibiotics by agar dilution method according to the approved standard of CLIS.Results Among 96 strains of streptococcus pneumoniae,63 (65.6%) strains were resistant to penicillin (MIC≥2 mg/L).87.5%,29.2%,8.3% and 4.2% of streptococcus pneumoniae were resistant against the cefuroxime,cefotaxim,amoxicillin,and ceftriaxone,retrospectively.The resistance rates to other antibiotic agents,such as erythromycin,azithromycin,tetracycline,and Chloram-phenicol were 96.9%,95.8%,95.8%,94.8%,respectively.All 96 strains of streptococcus pneumoniae were sensitive to vancomycin,tigecycline and linezolid.Conclusion The antibiotic resistance to streptococcus pneumoniae is serious in Nanjing.Most of them are multi-resistant strains.Except for vancomycin，tigecycline，linezolid，and ceftriaxone,most antibiotic agents have lost the reactivities against streptococcus pneumoniae.

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相似文献/References:

[1]刘 青,施 毅.肺炎链球菌肺炎诊治进展[J].医学研究与战创伤救治(原医学研究生学报),2013,15(05):499.[doi:10.3969/j.issn.1672-271X.2013.05.023]
[2]方 健,宋海燕,陈从新,等.一起小规模群体肺炎链球菌感染流行的报告[J].医学研究与战创伤救治(原医学研究生学报),2011,13(06):485.
　FANG Jian,SONG Hai-yan,CHEN Cong-xin,et al.The prevalence of streptococcus pneumoniae among a military camp[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(04):485.

备注/Memo

备注/Memo:
江苏省社会科技发展基金(BS2005051);南京军区医药卫生科研基金(06MA109)
更新日期/Last Update: 2011-07-20