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[1]李 颖,刘英娜,覃仕化,等.类风湿性关节炎患者韧带及关节囊组织炎性浸润机制研究[J].医学研究与战创伤救治(原医学研究生学报),2011,13(04):314-316.
　LI Ying,LIU Ying-na,QIN Shi-hua,et al.Tissue damage mechanism of ligament and joint capsule injury in patients with rheumatoid arthritis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(04):314-316.
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类风湿性关节炎患者韧带及关节囊组织炎性浸润机制研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年04期
页码:
314-316
栏目:
出版日期:
2011-07-20

文章信息/Info

Title:
Tissue damage mechanism of ligament and joint capsule injury in patients with rheumatoid arthritis
文章编号:
1672-271X(2011)04-0314-03
作者:
李 颖1; 刘英娜2; 覃仕化1; 杨俊生2; 冷冬妮2; 王 珺2; 杜秀銮2; 汪 悦1
1.210000 江苏南京，南京中医药大学；2.210002 江苏南京，解放军454医院骨科
Author(s):
LI Ying1; LIU Ying-na2; QIN Shi-hua1; YANG Jun-sheng2; LENG Dong-ni2; WANG Jun2; DU Xiu-luan2; WANG Yue1
1.Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210000,China;2.Department of Orthopedics,454 Hospital of PLA,Nanjing,Jiangsu 210002,China
关键词:
肿瘤坏死因子-α; 韧带; 关节囊; 类风湿性关节炎
Keywords:
TNF-α;  ligament;  joint capsule;  rheumatoid arthritis
分类号:
R593.22
DOI:
-
文献标志码:
A
摘要:
目的 探讨类风湿性关节炎患者的韧带及关节囊组织的浸润机制，为临床针对类风湿性关节炎患者关节周围软组织保护的药物筛选提供新的思路。方法 收集27例关节置换术中切取的关节囊和部分韧带组织，其中类风湿性关节炎(RA)6例，骨性关节炎(OA)9例，关节创伤(AT)12例，观察关节囊和韧带组织大体病变，光学显微镜下病理切片检查，并行组织匀浆免疫组化检测肿瘤坏死因子-α(TNF-α)水平。结果 RA组的关节囊和韧带组织明显增厚，平均厚度0.81 cm，镜下见韧带及关节囊组织中血管扩张，周围淋巴细胞浸润，纤维、胶原细胞增生，淋巴细胞数量明显多于OA组；RA组、OA组髋关节囊前壁厚度与AT组比较，差异有显著性(P<0.05)；RA组与OA组比较，无明显差异(P>0.05)。RA组、OA组的关节囊和韧带组织匀浆中TNF-α水平与AT组比较，有显著差异(P<0.01)；RA组与OA组比较，无明显差异(P>0.05)。结论 RA患者的韧带及关节囊组织的病变是血管扩张后的炎性细胞的浸润过程，是一个慢性非特异性炎性浸润过程，与关节滑膜组织及血管翳的关系不大。RA的浸润过程与OA的炎性过程基本相同，但是炎性细胞浸润在数量上明显多于OA。
Abstract:
Objective To investigate the infiltration mechanism of ligament and joint capsule in patients with rheumatoid arthritis (RA),with new ideas of screening drug for clinical protection against RA.Methods The part of the joint capsule and ligament tissues of 27 cases underwent joint replacement surgery were collected,including RA 6 cases,osteoarthritis (OA) 9 cases,and joint trauma (AT) 12 cases.The joint capsule and ligament were observed in general lesions,pathological examination under the light microscope,and TNF-α levels of tissue immunohistochemistry.Results The joint capsule and ligament tissue of RA patients was significantly thicker (0.81 cm in the average),with vasodilatation,lymphocyte infiltration surrounded,fibrosis,and collagen proliferation in the microscope.The number of lymphocytes in RA group was significantly more than that in OA group.The front wall thicknesses of the hip joint capsule with both RA group and OA group compared with AT group,the differences were significant (P<0.05),and there was no difference between RA group and OA group(P>0.05).The levels of TNF-α in both RA group and OA group compared with AT group,the differences were significant (P<0.05),and there was no difference between RA group and OA group(P>0.05).Conclusion The pathological mechanism of RA patients ligament and joint capsule tissue is inflammatory cell infiltration after the vasodilatation process,which is a process of chronic non-specific inflammatory infiltration,and has little to do with synovial membrane tissue and pannus.The infiltration processes of RA and that of OA are basically the same and the difference is that the number of inflammatory cell is significantly more than OA.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2011-07-20