|本期目录/Table of Contents|

[1]徐若男,陈 烁,刘宏滨,等.缓激肽B2受体基因多态性在膝骨关节炎发生和发展中的作用[J].医学研究与战创伤救治(原医学研究生学报),2013,15(04):361-364.[doi:10.3969/j.issn.1672-271X.2013.04.014]
　XU Ruo-nan,CHEN Shuo,LIU Hong-bin,et al.Bradykinin B2 receptor polymorphisms contribute to the susceptibility and severity of knee osteoarthritis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(04):361-364.[doi:10.3969/j.issn.1672-271X.2013.04.014]
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缓激肽B2受体基因多态性在膝骨关节炎发生和发展中的作用()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年04期
页码:
361-364
栏目:
出版日期:
2013-08-05

文章信息/Info

Title:
Bradykinin B2 receptor polymorphisms contribute to the susceptibility and severity of knee osteoarthritis
作者:
徐若男1; 陈 烁2; 刘宏滨2; 蔡筱松2
1.210002 江苏南京,南京军区南京总医院保健办; 2.221004 江苏徐州,解放军97医院骨科
Author(s):
XU Ruo-nan1; CHEN Shuo2; LIU Hong-bin2; CAI Xiao-song2
1.Offices of Health Care,Nanjing General Hospital of Nanjing Military Command,Nanjing,Jiangsu 210002,China; 2.Department of Orthopedics Surgery,97 Hospital of PLA,Xuzhou,Jiangsu 221004,China
关键词:
缓激肽B2受体;  基因多态性;  骨关节炎
Keywords:
bradykinin B2 receptor;  polymorphisms;  osteoarthritis
分类号:
R684.3
DOI:
10.3969/j.issn.1672-271X.2013.04.014
文献标志码:
A
摘要:
目的 研究缓激肽B2受体(BDKRB2)基因多态性对膝骨关节炎易感性和严重性的影响。方法 在原发性膝骨关节炎245例(观察组)及健康志愿者264例(对照组)中,针对BDKRB2基因多态性-58T/C和+9/-9,分别进行基因型测定。结果 +9/-9基因多态性的基因型分布和等位基因频率,在两组之间存在明显差异。回归分析显示-9/-9基因型相对于+9/+9基因型,罹患膝关节骨关节炎的风险明显增高(OR=2.354,P<0.01)。同时,+9/-9基因多态性与骨关节炎的放射学分型存在相关性,-9等位基因可能与骨关节炎的严重程度有关。-58T/C基因多态性与骨关节炎的易感性和严重性无相关性。结论 缓激肽B2受体基因多态性+9/-9可能成为检测骨关节炎易感性和严重性的基因标记物。
Abstract:
Objective To study the effect of bradykinin B2 receptor polymorphisms on the susceptibility and severity of knee osteoarthritis.Methods A total of 245 patients with primary knee OA and 264 healthy volunteer were recruited.BDKRB2 gene polymorphisms,-58T/C and +9/-9 polymorphisms,were genotyped.Results The genotype distributions and allele frequencies of +9/-9 polymorphisms significantly differed between OA and control subjects.Logistic regression analysis showed carriers with -9/-9 genotype had a significantly increased risk for knee OA compared with the +9/+9 genotype(OR=2.354,P<0.001).The +9/-9 polymorphisms also determined the OA radiographic severity.The presence of -9 was associated with severer OA.The -58T/C polymorphisms did not affect OA risk and severity.Conclusion The +9/-9 polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-08-05