|本期目录/Table of Contents|

[1]王 静,彭永平,宫剑滨,等.前列地尔对冠心病合并糖尿病患者介入治疗后造影剂肾病的影响[J].医学研究与战创伤救治(原医学研究生学报),2014,16(01):28-30.
　WANG Jing,PENG Yong-ping,GONG Jian-bin,et al.Effect of alprostadil on contrast-induced nephropathy in coronary heart disease patients with type 2 diabetes undergoing percutaneous coronary intervention[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(01):28-30.
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前列地尔对冠心病合并糖尿病患者介入治疗后造影剂肾病的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年01期
页码:
28-30
栏目:
出版日期:
2014-02-20

文章信息/Info

Title:
Effect of alprostadil on contrast-induced nephropathy in coronary heart disease patients with type 2 diabetes undergoing percutaneous coronary intervention
作者:
王 静; 彭永平; 宫剑滨; 蔡晓敏; 刘挺松
210002 江苏南京，南京军区南京总医院心脏内科
Author(s):
WANG Jing; PENG Yong-ping; GONG Jian-bin; CAI Xiao-min; LIU Ting-song.
Department of Cardiology，Nanjing General Hospital of Nanjing Military Command，Nanjing，Jiangsu 210002，China
关键词:
2型糖尿病; 冠心病; 造影剂肾病;  前列地尔
Keywords:
type 2 diabetes;  coronary heart disease;  contrast medium-induced nephropathy;  alprostadil
分类号:
R692
DOI:
-
文献标志码:
A
摘要:
目的 探讨前列地尔对防治冠心病合并糖尿病患者经皮冠状动脉介入治疗(PCI)后造影剂肾病的有效性。方法 将158例冠心病合并糖尿病患者随机分为常规治疗组(81例)和前列地尔组(77例)。常规治疗组(对照组)常规给予抗血小板聚集、降血脂及水化等治疗；前列地尔组(治疗组)PCI术开始前30 min给予前列地尔脂微球载体制剂10 μg经100 ml生理盐水稀释后经静脉滴入，术后连续静脉注射3 d;然后分别测定并比较两组患者造影后24 h、72 h的血肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(GFR)和造影剂肾病(CIN)的发生率。结果 两组患者术后72 h治疗组BUN及Scr增加值和增加百分比明显低于对照组(P＜0.05)，GFR下降值和下降比率以及CIN的发生率亦明显低于对照组(P＜0.05)。结论 应用前列地尔可能对于冠心病合并糖尿病患者PCI术后造影剂肾病的发生具有一定的预防保护作用。[关键词] 2型糖尿病；冠心病；造影剂肾病; 前列地尔
Abstract:
Objective To investigate the protective effect of alprostadil for coronary heart disease patients with type 2 diabetes on contrast medium-induced nephropathy (CIN) after percutaneous coronary intervention (PCI).Methods 158 coronary heart disease patients with type 2 diabetes from April 2012 to July 2013 who underwent percutaneous coronary intervention (PCI) were randomly divided into two groups:control group (n=81) and treatment group (n=77).Control group received conventional therapy including anti-platelet aggregation,blood lipid lowering,and hy-dration,while treatment group received 10 μg of alprostadil in 100 ml sodium chloride solution 30 min before PCI and lasted for 3 days after the operation.BUN,Scr,GFR and incidouence rate of CIN were measured and compared 24 and 72 hours after percutaneous coronary intervention (PCI) between groups.Results 72 hours after therapy,BUN,Scr values and percentage of increase,GFR values and percentage of decrease.The difference of the incidence of contrast-induced nephropathy between the two group was significant (P<0.05).Conclusion Alprostadil may provide substantial preventing prevention against contrast medium-induced nephropathy(CIN) on coronary heart disease patients with type 2 diabetes.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2014-01-20