|本期目录/Table of Contents|

[1]王兴元,曹红兵,周红霞,等.前驱糖尿病对冠心病侧支循环形成的影响[J].医学研究与战创伤救治(原医学研究生学报),2011,13(04):327-329.
 WANG Xing-yuan,CAO Hong-bin,ZHOU Hong-xia,et al.Influence of prediabetes on coronary collateral formation in patients with documented occlude coronary arteries[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(04):327-329.
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前驱糖尿病对冠心病侧支循环形成的影响()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年04期
页码:
327-329
栏目:
出版日期:
2011-07-20

文章信息/Info

Title:
Influence of prediabetes on coronary collateral formation in patients with documented occlude coronary arteries
文章编号:
1672-271X(2011)04-0327-03
作者:
王兴元1曹红兵1周红霞1杨善进1施海明2罗心平2
1.212001 江苏镇江,解放军359医院内三科;2.200040 上海,上海复旦大学附属华山医院心内科
Author(s):
WANG Xing-yuan1CAO Hong-bin1ZHOU Hong-xia1YANG Shan-jin1SHI Hai-ming2LUO Xin-ping2.
1.359 Hospital of PLA,Zhenjiang,Jiangsu 212001,China;2.Department of Cardiology,Huashan Hospital,Fudan University,Shanghai 200040,China
关键词:
前驱糖尿病冠心病侧支循环
Keywords:
prediabetes coronary artery disease coronary collateral circulation
分类号:
R587.23
DOI:
-
文献标志码:
A
摘要:
目的 调查前驱糖尿病对冠状动脉侧支循环形成的影响。方法 对经冠状动脉造影证实至少有一个冠状动脉主支闭塞的患者713例进行研究。使用Rentrop计分系统评定侧支循环,0和1级评定为不良,2级和3级评定为良好。根据美国糖尿病协会标准确定前驱糖尿病并把患者分为前驱糖尿病组和正常对照组。其中321例患者纳入前驱糖尿病组,391例纳入正常对照组,进行比较。结果 前驱糖尿病组的不良冠脉侧支循环(coronary collateral circulation,CCC)比例较高,与正常对照组比较差异有统计学意义(P<0.01)。逻辑回归分析提示空腹血糖是CCC独立的预测因子(P<0.01,优势比=0.878)。结论 本研究提示,同正常空腹血糖患者相比,前驱糖尿病影响了侧支循环的形成。
Abstract:
Objective To determine the influence of prediabetes on coronary collateral development in patients with coronary artery disease.Methods 713 patients with at least one coronary occlusion of a major coronary vessel at diagnostic angiography were retrospectively enrolled.Collateral development was graded with Rentrops scoring system.Rentrop grades of 0 and 1 indicate poor CCC whereas 2 and 3 indicate good CCC.The prediabetes was defined according to American Diabetes Association definition and patients were then divided into having prediabetes group (321 patients) and control group (391 patients).Results Compared with control group,poor CCC was higher in the prediabetes group (P<0.01).Multivariable logistic regression analysis showed that fast glucose level was the only independent predictor of CCC (P<0.01,odds ratio=0.878).Conclusion This study shows that in patients with coronary occlusion,collateral circulation is impaired in patients with prediabetes when compared to patients with coronary artery disease who had normal fast glucose level.

参考文献/References:

[1]Kilmer G,Hughes E,Zhang X,et al.Diabetes and prediabetes: Screening and prevalence among adults with coronary heart disease [J].Am J Prev Med,2011,40(2):159-165.
[2]Barr EL,Zimmet PZ,Welborn TA,et al.Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus,impaired fasting glucose,and impaired glucose tolerance: The australian diabetes,obesity,and lifestyle study (ausdiab)[J].Circulation,2007,116(2):151-157.
[3]Weihrauch D,Lohr NL,Mraovic B,et al.Chronic hyperglycemia attenuates coronary collateral development and impairs proliferative properties of myocardial interstitial fluid by production of angiostatin [J].Circulation,2004,109(19):2343-2348.
[4]Yilmaz MB,Caldir V,Guray Y,et al.Relation of coronary collateral vessel development in patients with a totally occluded right coronary artery to the metabolic syndrome [J].Am J Cardiol,2006,97(5):636-639.
[5]Mouquet F,Cuilleret F,Susen S,et al.Metabolic syndrome and c-ollateral vessel formation in patients with documented occluded coronary arteries: association with hyperglycaemia,insulin-resistance,adiponectin and plasminogen activator inhibitor-1 [J].Eur Heart J,2009,30(7):840-849.
[6]Rentrop KP,Cohen M,Blanke H,et al.Changes in collateral ch-annel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects [J].J Am Coll Cardiol,1985,5(3):587-592.
[7]Diagnosis and classification of diabetes mellitus [J].Diabetes Care,2008,31(Suppl 1):S55-S60.
[8]Executive summary of the third report of the national cholesterol education program (ncep) expert panel on detection,evaluation,and treatment of high blood cholesterol in adults (adult treatment panel iii)[J].Jama,2001,285(19):2486-2497.
[9]van Golde JM,Ruiter MS,Schaper NC,et al.Impaired collateral recruitment and outward remodeling in experimental diabetes [J].Diabetes,2008,57(10):2818-2823.
[10]Choi EK,Kim HS,Park KW,et al.Novel index of coronary collateral development as a useful predictor of clinical outcome in type 2 diabetic patients with coronary artery disease [J].Circ J,2005,69(7):786-792.
[11]Marfella R,Esposito K,Nappo F,et al.Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes [J].Diabetes,2004,53(9):2383-2391.
[12]Sasmaz H,Yilmaz MB.Coronary collaterals in obese patients: Impact of metabolic syndrome [J].Angiology,2009,60(2):164-168.
[13]Matsunaga T,Weihrauch DW,Moniz MC,et al.Angiostatin inhibits coronary angiogenesis during impaired production of nitric oxide [J].Circulation,2002,105(18):2185-2191.
[14]Milman S,Crandall JP.Mechanisms of vascular complications in prediabetes [J].Med Clin North Am,2011,95(2):309-325,Ⅶ.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2011-07-20