|本期目录/Table of Contents|

[1]朱元元,杨双旺,邱彦.硝酸镓可降解涂层的体外抗菌实验[J].医学研究与战创伤救治(原医学研究生学报),2014,16(04):346-348.[doi:10.3969/j.issn.1672-271X.2014.04.004]
　ZHU Yuan-yuan,YANG Shuang-wang,QIU Yan..Evaluation of antimicrobial efficacy of gallium-coated PVC in vitro[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(04):346-348.[doi:10.3969/j.issn.1672-271X.2014.04.004]
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硝酸镓可降解涂层的体外抗菌实验()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年04期
页码:
346-348
栏目:
出版日期:
2014-07-31

文章信息/Info

Title:
Evaluation of antimicrobial efficacy of gallium-coated PVC in vitro
作者:
朱元元1; 杨双旺2; 邱彦3
210002 江苏南京，解放军454医院,1.院办公室,2.感控科,3.药剂科
Author(s):
ZHU Yuan-yuan1; YANG Shuang-wang2; QIU Yan3.
1.Department of Administration,2.Department of Infection Control,3.Department of Pharmacy,454 Hospital of PLA,Nanjing，Jiangsu 210002,China
关键词:
医疗器械; 硝酸镓; 涂层; 抗菌活性; 细胞黏附
Keywords:
medical devices;  gallium nitrate;  coating;  antimicrobial activity;  bacterial adherence
分类号:
R318.08
DOI:
10.3969/j.issn.1672-271X.2014.04.004
文献标志码:
A
摘要:
目的 铜绿假单胞菌是医疗器械相关感染的主要致病菌,其持续感染的特性被认为与其具有形成附着生物膜的能力有关。本研究探讨硝酸镓涂膜对形成生物膜的抑制作用。方法 将硝酸镓、明胶、EDTA按照一定的比例混合后涂于聚氯乙烯(PVC)片表面，然后采用Kirby-Bauer法考察铜绿假单胞菌在PVC表面形成生物膜的情况并进行评估。结果 表面涂有硝酸镓的PVC板在铜绿假单胞菌平板上形成的抑菌圈的直径大于20 mm，减少了细菌在表面的聚集并抑制了生物膜的形成。结论 用硝酸镓涂膜对PVC表面进行前处理可抑制铜绿假单胞菌的生长和生物膜的形成。
Abstract:
Objective Pseudomonas aeruginosa is one of the main bacterial stain that cause device-associated infections.Pseudomonas aeruginosa may adhere to the surface of devices and form biofilm,which is responsible for the persistent infection.The present study was aimed to test the antimicrobial efficacy of gallium-coated PVC.Methods The antimicrobial efficacy of PVC segments coated through an instant dip method with gallium was determined.Using the modified Kirby-Bauer method,gallium-coated PVC against Pseudomonas aeruginosa was evaluated.Results Gallium-coated PVC maintained a zone of inhibition of >20 mm against Pseudomonas aeruginosa for 1 week.Gallium-coated PVC significantly reduced the amount of viable Pseudomonas aeruginosa organisms adhering to their surfaces when compared with control.Conclusion Gallium-coated PVC impregnated using an instantaneous dip method,were shown to have prolonged antimicrobial durability and high efficacy in inhibiting adherence of Pseudomonas aeruginosa to PVC surface and formation of biofilm.

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相似文献/References:

[1]朱元元.硝酸镓和万古霉素抑制表皮葡萄球菌生物膜形成的协同作用[J].医学研究与战创伤救治(原医学研究生学报),2009,11(06):499.
　ZHU Yuan-yuan.Inhibition of staphylococcus epidermidis biofilm by a combination of gallium nitrate and vancomycin[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(04):499.

备注/Memo

备注/Memo:
南京军区医学科技创新课题(08MA54)
更新日期/Last Update: 2014-07-20