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[1]薛 路,郭彦敏,沈 洋,等.急性脑梗死患者血清抵抗素及血清淀粉样蛋白A水平与病情的相关性[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):404-406.[doi:10.3969/j.issn.1672-271X.2015.04.022]
　XUE Lu,GUO Yan-min,SHEN Yang,et al.The relevance of serum amyloid A protein and resistin level to acute cerebral infarction[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(04):404-406.[doi:10.3969/j.issn.1672-271X.2015.04.022]
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急性脑梗死患者血清抵抗素及血清淀粉样蛋白A水平与病情的相关性()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年04期
页码:
404-406
栏目:
出版日期:
2015-07-20

文章信息/Info

Title:
The relevance of serum amyloid A protein and resistin level to acute cerebral infarction
作者:
薛 路1; 郭彦敏1; 沈 洋1; 张会凯2
1.050700 河北新乐，河北省新乐市医院人事科；2.050700 河北新乐，河北省新乐市中医医院老年病科
Author(s):
XUE Lu1;  GUO Yan-min1;  SHEN Yang1;  ZHANG Hui-kai2.
1.Personnel Department， Xinle Hospital， Xinle， Hebei 050700， China；2.Geriatrics Department， Xinle Hospital of Traditional Chinese Medicine， Xinle， Hebei 050700， China
关键词:
急性脑梗死; 血清抵抗素; 血清淀粉样蛋白A; 美国国立卫生研究院卒中量表评分
Keywords:
acute cerebral infarction;  resistin;  serum amyloid A;  National Institute of Health stroke scale
分类号:
R541.4
DOI:
10.3969/j.issn.1672-271X.2015.04.022
文献标志码:
A
摘要:
目的 探讨急性脑梗死患者血清抵抗素(resistin)及血清淀粉样蛋白A(serum amyloid A，SAA)与病情程度的相关性。 方法 选择2014年1－6月在某院住院的急性脑梗死患者53例作为观察组；同期健康体检者35例作为对照组。两组患者均空腹采血，测定血清抵抗素及SAA水平，采用美国国立卫生研究院卒中量表(National Institute of Health stroke scale，NIHSS)在入院24 h内对观察组进行评分。 结果 观察组NIHSS评分＜5分18例(33.96%)，5~15分23例(43.40%)，＞15分12例(22.64%)。观察组与对照组比较，血清抵抗素、SAA水平明显增高(P均＜0.05)。观察组血清抵抗素、SAA水平与NIHSS评分之间均呈正相关(r分别为0.946、0.978，P均＜0.05)。 结论 急性脑梗死患者血清抵抗素、SAA水平明显高于正常健康人，血清抵抗素SAA水平与NIHSS评分均呈正相关。
Abstract:
Objective To observe the change of serum amyloid A Protein (SAA) and resistin Level to acute cerebral infarction. Methods 53 patients with acute cerebral infarction were selected as the experimental group, and 35 healthy volunteers as the control group. The level of serum SAA and resistin were detected by ELISA method in the two groups, the NIHSS score were carried out in research group within 24 h of admission. Results National Institute of Health stroke scale (NIHSS) was carried out in the experimental group within 24 h to determine the degree of neurological deficiency: mild in 18 cases (<5， 33.96%), moderate in 23 cases (5-15， 43.40%), severe in 12 cases (>15, 22.64%). Compare with the control group, serum SAA and resistin level of the experimental group was increased (P<0.05). Correlation analysis between the serum SAA, resistin level and the NIHSS score in the experimental group demonstrated a positive correlation between serum SAA level with NIHSS score (r=0.946, P<0.05); and a positive correlation between the level of serum resistin and NIHSS score (r=0.978, P<0.05). Conclusion Serum SAA and resistin level in patients with Acute cerebral infarction significantly higher than those in healthy people. Serum SAA and resistin level of the experimental group were positively correlated with NIHSS score.

参考文献/References:

［1］吴金飞，陈传琳，曾素琴，等.脑梗死危险因素及生化特征分析［J］.东南国防医药，2014，16(3):270-272.
［2］吴修信，李立新，廖品君，等.急性脑梗死患者血清淀粉样蛋白A的临床和预后价值［J］.首都医科大学学报，2012，33(2):255-258.
［3］中华医学会全国第四届脑血管病学术会议.各类脑血管疾病诊断要点［J］.中华神经杂志，1996，29(6):379-382.
［4］诸兴明，陈 阳，杜宇平，等.急性脑梗死患者血清胱抑素C和C反应蛋白水平变化的研究［J］.东南国防医药，2014，16(3):275-277.
［5］耿红莲，仲人前.血清淀粉样物质Ａ研究进展［J］.现代检验医学杂志，2010，25(4):10-12.
［6］夏章勇，杨 华，崔可密，等.脑卒中患者急性期血浆抵抗素和瘦素水平及其相关性研究［J］.中华老年心血管病杂志，2006，8:329-332.
［7］崔海月，王庆国.缺血性脑血管病发病机制的新进展［J］.长春中医药大学学报，2009，25(2):291-292.
［8］曹建伟.急性脑梗死患者血清抵抗素水平变化及意义［J］.山东医药，2013，53(9):50-52.
［9］Weikert C，Westphal S，Berger K，et al.Plasma resistin levels and risk of myocardial infarction and ischemic stroke［J］.J Clin Endocrinol Metab，2008，93(7):2647-2653.
［10］曾素琴，熊 宁，吕仁发.颈动脉粥样硬化与脑梗死关系的探讨［J］.东南国防医药，2011，13(3):500-502.
［11］孙增强.血清淀粉样蛋白A和血清C反应蛋白与急性脑梗死关系的临床研究［D］.青岛大学，2014.
［12］Schillinger M，Exner M，Lekusch W，et al.Inflammation and Carotid Artery Risk for Atherosclerosis Study (ICARAS)［J］.Circulation，2005，111(17):2203-2209.

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备注/Memo

备注/Memo:
石家庄市科学技术研究与发展计划资金支持项目(141462103)
更新日期/Last Update: 2015-07-20