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[1]吴鸿雁,黄睿,熊亚莉,等.不同病因慢性肝病患者肝组织中IL-10的表达及意义[J].医学研究与战创伤救治(原医学研究生学报),2016,18(02):122-124,141.[doi:10.3969/j.issn.1672-271X.2016.02.004]
　WU Hong-yan,HUANG Rui,XIONG Ya-li,et al.Expression of interleukin-10 in the liver tissues of patients with chronic liver diseases of different etiologies[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(02):122-124,141.[doi:10.3969/j.issn.1672-271X.2016.02.004]
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不同病因慢性肝病患者肝组织中IL-10的表达及意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年02期
页码:
122-124,141
栏目:
出版日期:
2016-04-09

文章信息/Info

Title:
Expression of interleukin-10 in the liver tissues of patients with chronic liver diseases of different etiologies
作者:
吴鸿雁1; 黄睿2; 熊亚莉2; 陈锦1; 孙珍花2; 王贵阳2; 吴超2
210008 江苏南京，南京大学医学院附属鼓楼医院,1. 病理科,2. 感染科
Author(s):
WU Hong-yan1;  HUANG Rui2;  XIONG Ya-li2;  CHEN Jin1;  SUN Zhen-hua2;  WANG Gui-yang2;  WU Chao2.
1.Department of Pathology, 2. Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China
关键词:
慢性肝病; 白细胞介素-10; 炎症; 肝纤维化
Keywords:
chronic liver disease;  interleukin-10;  inflammation;  liver fibrosis
分类号:
R575
DOI:
10.3969/j.issn.1672-271X.2016.02.004
文献标志码:
A
摘要:
目的 探讨不同病因的慢性肝病（CLD）患者肝组织中白细胞介素-10（IL-10）的表达及其与肝组织炎症和纤维化的关系。方法 收集93例CLD患者及23例正常对照肝 组织石蜡标本，免疫组织化学方法检测肝组织中IL-10的表达。结果 不同病因的CLD患者肝组织中肝小叶及汇管区IL-10的表达均较正常对照明显增高（P<0.01）。随着肝脏炎症分 级（G）的增高，CLD患者肝组织内肝小叶及汇管区IL-10的表达逐渐增强，差异有统计学意义。随着肝脏纤维化程度分期（S）的增高，CLD患者肝组织内肝小叶及汇管区IL-10的表 达亦逐渐增高，差异有统计学意义。结论 IL-10可能参与CLD患者肝脏的炎症和纤维化的发生。
Abstract:
Objective To investigate the expression of interleukin-10 (IL-10) in the liver tissues of patients with chronic liver diseases (CLD) and determine its association with liver inflammation and liver fibrosis. Methods A total of 93 patients with different types of CLD were enrolled in our study. Twenty-three normal liver tissues were included as control. The expression of IL-10 was determined by immunohistochemistry in the formalin-fixed, paraffin- embedded liver tissues of CLD patients and healthy controls. Results The expression of IL-10 was significantly increased in both hepatic lobule and portal area of liver tissues of CLD patients with different etiologies as compared with normal controls (P<0.01). CLD patients with high inflammation grades (G) had higher IL-10 expression in hepatic lobule and portal area of liver tissues compared to those with lower grades. Significantly higher IL-10 expression was found in hepatic lobule and portal area of liver tissues of CLD patients with high fibrotic stages (S) compared to those with lower stages. Conclusion IL-10 may play a pathological role in chronic liver inflammation and fibrosis in CLD.

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备注/Memo

备注/Memo:
南京市医学科技发展项目（YKK13065）
更新日期/Last Update: 2016-03-20