|本期目录/Table of Contents|

[1]纪婷婷,张梦辉,陶明月,等.结肠癌患者术前红细胞分布宽度与术后存活率的相关性分析[J].医学研究与战创伤救治(原医学研究生学报),2019,21(4):374-377.[doi:10.3969/j.issn.1672-271X.2019.04.009]
 JI Ting-ting,ZHANG Meng-hui,TAO Ming-yue,et al.The effect of preoperative the red cell volume distribution width on postoperative survival of colon cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(4):374-377.[doi:10.3969/j.issn.1672-271X.2019.04.009]
点击复制

结肠癌患者术前红细胞分布宽度与术后存活率的相关性分析()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年4期
页码:
374-377
栏目:
临床研究
出版日期:
2019-07-20

文章信息/Info

Title:
The effect of preoperative the red cell volume distribution width on postoperative survival of colon cancer
文章编号:
1672-271X(2019)04-0374-04
作者:
纪婷婷张梦辉陶明月周静芳马天恒石运涛王海啸王宏刚
作者单位:223300 淮安,南京医科大学附属淮安第一医院血液科(纪婷婷),消化内科(张梦辉、周静芳、马天恒、石运涛、王宏刚),肿瘤内科(陶明月),胃肠外科(王海啸)
Author(s):
JI Ting-ting1 ZHANG Meng-hui2 TAO Ming-yue3 ZHOU Jing-fang2 MA Tian-heng2 SHI Yun-tao2 WANG Hai-xiao4 WANG Hong-gang2
(Department of Hematology)
关键词:
红细胞分布宽度 结肠癌 溃疡性结肠炎 存活率
Keywords:
red blood cell distribution width colon cancer ulcerative colitis survival rate
分类号:
R735.35
DOI:
10.3969/j.issn.1672-271X.2019.04.009
文献标志码:
A
摘要:
目的 探讨结肠癌患者术前红细胞分布宽度(RDW)与患者术后存活率的相关性。 方法 回顾性分析2011年1月至2013年12月于南京医科大学附属淮安第一医院接受外科手术治疗的结肠癌119例患者的临床资料,并随机选取同期住院诊治的溃疡性结肠炎(UC)119例作为对照,比较结肠癌患者和UC患者外周血RDW的差异。同时以结肠癌患者术前的RDW均值为界将其分为高RDW组和低RDW组,对其术后进行长期随访,分析RDW与术后存活率之间的相关性。 结果 结肠癌患者的RDW高于UC患者[(43.48±4.06)% vs (41.76±4.93)%,P<0.01]。结肠癌患者术前RDW与癌胚抗原(CEA)呈显著正相关(r=0.748,P<0.01)。RDW与肿瘤位置、肿瘤大小、病理分级、肿瘤浸润深度、术后病理淋巴结是否阳性均无关(P>0.05),且与患者术后1年的存活率无关(P>0.05)。高RDW组在术后3年和5年的存活率明显低于低RDW组(68.6% vs 85.3%,40.0% vs 75.0%),差异均有统计学意义(P<0.05)。 结论 结肠癌患者术前RDW水平与术后3年和5年存活率有一定相关性,可作为判断结肠癌术后存活率的一个重要指标。
Abstract:
Objective To explore the correlation between the red cell volume distribution width (RDW) and postoperative survival rate of patients with colon cancer. Methods Total 119 patients with colon cancer who received surgical treatment from Januray 2011 to December 2013 in The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University were enrolled. Total 119 cases with ulcerative colitis (UC) at the same period in our hospital were randomly selected as control group to compare the difference of RDW in peripheral blood. Meanwhile,colon cancer patients were divided into the higher RDW group and the lower RDW group by the mean of preoperative RDW. The correlation between RDW and postoperative survival was analyzed based on long-term follow-up of patients with colon cancer. Results RDW in patients with colon cancer was higher than that of UC patients[(43.48±4.06)% vs (41.76±4.93)%,P<0.01]. Preoperative RDW of colon cancer was positively correlated with CEA(r=0.748,P<0.01). RDW was not associated with tumor location,tumor size,pathological grading,tumor infiltration depth,postoperative pathological lymph node involvement(P>0.05),and the survival rate of one year after surgery(P>0.05). However,the survival rate at three years and five years after surgery in preoperative higher RDW group was significantly lower than that of lower RDW group. The survival rate at three years after surgery of the two groups were 68.6% and 85.3%,and the survival rate at five years were 40.0% and 75.0%,respectively. The differences were statistically significant (P<0.05). Conclusion In higher preoperative RDW patients with colon cancer,the survival rate at three and five years after surgery was lower. Preoperative RDW may be a novel indicator for postoperative survival of colon cancer.

参考文献/References:

1 李云春,钟利,王悦,等.类风湿性关节炎患者红细胞体积分布宽度及相关炎性因子与病情活动度的相关性[J].检验医学,2017,32(4):304-307.
2 提长斌,卢清龙,侯运辉,等.急性胰腺炎患者红细胞体积分布宽度与炎症标志物的关系[J].检验医学与临床,2017,14(16):2359-2360.
3 YuyunD,ZhihuaT,HaijunW,et al.Predictive value of the red blood cell distribution width-to-platelet ratio for hepatic fibrosis[J].Scand J Gastroenterol,2019,54(1):81-86.
4 孙广浩,张晓萍,邵润霞.慢性阻塞性肺疾病急性加重期红细胞分布宽度水平变化[J].实用医学杂志,2016,32(11):1797-1799.
5 王苏梦,吴嘉,牛冬梅,等.急性冠脉综合征患者NT-proBNP、RDW和CRP的水平及相关性研究[J].东南国防医药,2015,17(4):362-364.
6 KiriuT,YamamotoM,NaganoT,et al.Prognostic Value of Red Blood Cell Distribution Width in Non-small Cell Lung Cancer Treated With Anti-programmed Cell Death-1 Antibody[J].In Vivo,2019,33(1):213-220.
7 周杨,于洋,张庆云,等.红细胞分布宽度对膀胱尿路上皮癌的诊断价值[J].广西医科大学学报,2016,33(1):77-79.
8 汪芳裕.溃疡性结肠炎相关大肠癌研究进展[J].东南国防医药,2013,15(4):376-380.
9 SongCS,Park DI,YoonMY,et al.Association between red cell distribution width and disease activity in patients with inflammatory bowel disease[J].Dig Dis Sci,2012,57(4):1033-1038.
10 贾静,陈颖,林露,等.胃癌患者术前NLR PLR RDW值与病理参数的关系[J].中国肿瘤临床,2017,44(2):78-82.
11 韩福燕,成士清,王召宝,等.食管癌患者外周血红细胞分布宽度检测的临床价值[J].山东大学学报(医学版),2017,55(7):67-72.
12 王彤,柯淑兰,陈礼平,等.高血压患者红细胞分布宽度与超敏C反应蛋白的相关性分析[J].浙江临床医学,2017,19(10):1811-1812.
13 高闯,杜晓博,王丹丹.白细胞介素22与炎症性肠病的研究进展[J].医学研究生学报,2018,31(11):1196-1200.
14 葛婷雯,崔久嵬.肿瘤与肿瘤炎症微环境相互促进机制研究进展[J].临床检验杂志,2017,35(11):832-835.
15 张瑞,朱娜,马静,等.一种溃疡性结肠炎相关性结肠癌小鼠模型的建立[J].山西医科大学学报,2016,47(8):720-723.
16 向旭,戴跃青.红细胞分布宽度与消化系统疾病关系的研究进展[J].胃肠病学和肝病学杂志,2017,26(7):812-815.
17 丛玉隆,孙芾,陈宝梁.当代血液分析技术与临床[M].北京:人民卫生出版社,1997:17-20.
18 吴钢,赵昌杰,陈林,等.PGⅠ、CA19-9及CEA水平对胃癌诊断与预后评估的价值[J].山西医科大学学报,2016,47(11):1001-1004.
19 王俊.探讨红细胞分布宽度与结肠癌患者的关系[D].温州医科大学,2016.
20 MitrugnoA,Tassi YungaS,SylmanJL,et al.The role of coagulation and platelets in colon cancer-associated thrombosis[J].Am J Physiol Cell Physiol,2019,316(2):C264-C273.
21 汪勇强,吴小微,王计,等.红细胞分布宽度与结直肠癌的关系[J].广西医学,2017,39(7):1005-1007.
22 韩福燕,成士清,王召宝,等.食管癌患者外周血红细胞分布宽度检测的临床价值[J].山东大学学报(医学版),2017,55(7):67-72.
23 徐央杰,李文峰.胃癌患者术前红细胞分布宽度与临床病理特征及预后的关系[J].浙江医学,2017,39(22):2008-2010.

相似文献/References:

[1]王苏梦,吴 嘉,牛冬梅,等.急性冠脉综合征患者NT-proBNP、RDW和CRP的水平及相关性研究[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):362.[doi:10.3969/j.issn.1672-271X.2015.04.008]
 WANG Su-meng,WU Jia,NIU Dong-mei,et al.Study of plasma level of NT-proBNP, CRP and RDW in acute coronary syndrome patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(4):362.[doi:10.3969/j.issn.1672-271X.2015.04.008]
[2]程小兵,陈燕,罗娟娟,等.红细胞分布宽度和血小板分布宽度的变化与急性心肌梗死疗效的关系[J].医学研究与战创伤救治(原医学研究生学报),2020,22(01):33.[doi:10.3969/j.issn.1672-271X.2020.01.008]
 CHENGXiao-bing,CHENYan,LUOJuan-juan,et al.Effects of acute myocardial infarction on the changes of erythrocyte distribution width and platelet distribution width[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(4):33.[doi:10.3969/j.issn.1672-271X.2020.01.008]
[3]马遥,刘南海,翁燕红,等.红细胞体积异质性与急性脑梗死患者中枢神经元细胞损伤的关系[J].医学研究与战创伤救治(原医学研究生学报),2021,23(05):484.[doi:10.3969/j.issn.1672-271X.2021.05.008]
 MA Yao,LIU Nan-hai,WENG Yan-hong,et al.Relationship between red blood cell volume heterogeneity and central neurons injury in patients with acute ischemic stroke[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(4):484.[doi:10.3969/j.issn.1672-271X.2021.05.008]

备注/Memo

备注/Memo:
收稿日期:2018-10-18
更新日期/Last Update: 2019-07-11