|本期目录/Table of Contents|

[1]陈媛媛,赵丽综述,汪芳裕,等.上消化道克罗恩病的临床特征及诊治现状与分析[J].医学研究与战创伤救治(原医学研究生学报),2020,22(4):385-389.[doi:10.3969/j.issn.1672-271X.2020.04.011]
　CHEN Yuan-yuan,ZHAO Li reviewing,WANG Fang-yu,et al.Clinical characteristics, diagnosis and treatment status and analysis of Crohn’s disease with upper gastrointestinal tract phenotype[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(4):385-389.[doi:10.3969/j.issn.1672-271X.2020.04.011]
点击复制

上消化道克罗恩病的临床特征及诊治现状与分析()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年4期
页码:
385-389
栏目:
综述
出版日期:
2020-07-20

文章信息/Info

Title:
Clinical characteristics, diagnosis and treatment status and analysis of Crohn’s disease with upper gastrointestinal tract phenotype
作者:
陈媛媛; 赵丽综述; 汪芳裕; 刘炯审校
作者单位：233030 蚌埠，蚌埠医学院（陈媛媛、赵丽）；210002 南京，东部战区总医院（原南京军区南京总医院）消化内科（汪芳裕、刘炯）
Author(s):
CHEN Yuan-yuan1;  ZHAO Li1 reviewing;  WANG Fang-yu2;  LIU Jiong checking2
(1.School of Graduate, Bengbu Medical College, Bengbu 233030, Anhui, China; 2.Department of Gastroenterology, General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China)
关键词:
上消化道; 克罗恩病; 临床特征; 诊断; 治疗
Keywords:
upper digestive tract;  Crohn’s disease; clinical features;  diagnosis;  treatment
分类号:
R572.3
DOI:
10.3969/j.issn.1672-271X.2020.04.011
文献标志码:
A
摘要:
上消化道克罗恩病是一种报道不足，认识不足的克罗恩病表型。成人克罗恩病患者累及上消化道时，往往预示病情严重。胃镜检查和活检是最敏感的诊断检查。目前关于上消化道克罗恩病缺乏有效的治疗方法，先给予局部治疗，再进展到全身治疗，当患者出现并发症如严重的梗阻和穿孔、出血时，则需要外科干预，预后不良，危害患者的身心健康。文章主要就上消化道克罗恩病从口腔至十二指肠各个部位克罗恩病的特征、诊治现状及展望进行综述。
Abstract:
Upper gastrointestinal Crohn’s disease (CD) is an under-reported and under-recognized crohn’s disease phenotype. Adult CD patients with upper gastrointestinal involvement tend to predict a more severe crohn phenotype and a higher incidence of complications.Gastroscopy and biopsy are the most sensitive diagnostic tests. Currently, there is a lack of relevant research on crohn’s treatment of upper gastrointestinal tract. Treatment management is similar to that of ileocolic CD. Local treatment is given first, and then the treatment progresses to systemic treatment. When patients suffer from complications such as severe obstruction, perforation and bleeding, surgical intervention is required, and the prognosis is poor, endangering the physical and mental health of patients. This paper aims to summarize the characteristics, diagnosis and treatment status and prospects of the CD in various parts of upper gastrointestinal crohn’s disease from oral cavity to duodenum.

参考文献/References:

[1]Sun XW, Wei J, Yang Z, et al. Clinical Features and Prognosis of Crohn’s Disease with Upper Gastrointestinal Tract Phenotype in Chinese Patients[J]. Dig Dis Sci,2019, 64(11): 3291-3299.
[2]Laube R, Liu K, Schifter M, et al. Oral and upper gastrointestinal Crohn’s disease[J]. J Gastroenterol Hepatol, 2018,3(2):355-364.
[3]朱伟思. 上消化道克罗恩病临床特征及诊疗现状分析[D]. 广州：南方医科大学, 2015.
[4]Pimentel AM,Rocha R,Santana GO, et al. Crohn’s disease of esophagus, stomach and duodenum[J]. World J Gastrointest Pharmacol Ther, 2019,10(2): 35-49.
[5]Tan CX, Brand HS, de Boer NK, et al.Gastrointestinal diseases and their oro-dental manifestations: Part 1: Crohn’s disease[J]. Br Dent J, 2016,221(12): 794-799.
[6]Tan CXW,de Boer NKH,Brand HS, et al. Oral manifestations of Crohn’s disease[J]. Ned Tijdschr Tandheelkd, 2018, 125(1): 15-20.
[7]Schwartzberg DM,Brandstetter S,Grucela AL, et al. Crohn’s Disease of the Esophagus, Duodenum, and Stomach[J]. Clin Colon Rectal Surg, 2019,32(4): 231-242.
[8]Davis KG. Crohn’s Disease of the Foregut[J]. Surg Clin North Am, 2015,95(6): 1183-1193.
[9]Greuter T, Piller A,Fournier N, et al. Upper Gastrointestinal Tract Involvement in Crohn’s Disease: Frequency, Risk Factors, and Disease Course[J]. J Crohns Colitis, 2018, 12(12): 1399-1409.
[10]De Felice KM, Katzka DA, Raffals LE. Crohn s Disease of the Esophagus:Crohn’s Disease of the Esophagus: Clinical Features and Treatment Outcomes in the Biologic Era[J]. Inflamm Bowel Dis, 2015,21(9): 2106-2113.
[11]Nomura Y, Moriichi K, Fujiya M, et al. The endoscopic findings of the upper gastrointestinal tract in patients with Crohn’s disease[J]. Clin J Gastroenterol, 2017,10(4): 289-296.
[12]Singh A,Agrawal N,Kurada S,et al. Efficacy, Safety, and Long-term Outcome of Serial Endoscopic Balloon Dilation for Upper Gastrointestinal Crohn’s Disease-associated Strictures-A Cohort Study[J]. J Crohns Colitis, 2017, 11(9):1044-1051.
[13]Sato Y,Matsui T,Yano Y,et al. Long-term course of Crohn’s disease in Japan: Incidence of complications, cumulative rate of initial surgery, and risk factors at diagnosis for initial surgery[J]. J. Gastroenterol Hepatol,2015,30(12):1713-1719.
[14]Lightner AL,Fletcher JG. Duodenal Crohn’s Disease-a Diagnostic Conundrum[J]. J Gastrointest Surg, 2018,22(4):761-763.
[15]Ooi CJ,Makharia GK,Hilmi I,et al. Asia Pacific Consensus Statements on Crohn’s disease. Part 1: Definition, diagnosis, and epidemiology: (Asia Pacific Crohn’s Disease Consensus--Part 1)[J]. J Gastroenterol Hepatol, 2016,31:45-55.
[16]Mentzer A,Nayee S,Omar Y,et al. Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of Orofacial Granulomatosis[J]. Inflamm Bowel Dis, 2016,22:1552-1558.
[17]Farkas K, Chan H, Rutka M, et al. Gastroduodenal involvement in asymptomatic Crohn’s Disease patients in two areas of emerging disease: Asia and Eastern Europe[J]. J Crohns Colitis,2016, 10(12): 1401-1406.
[18]Grand D, Guglielmo F, Al-Hawary M. MR enterography in Crohn’s Disease: current consensus on optimal imaging technique and future advances from the SAR Crohn’s Disease-focused pannel[J]. Abdom Imaging, 2015,40:953-964.
[19]Ooi C, Makharia G, Hilmi I, et al. Asia-Pacific consensus statements on Crohn’s disease. Part 2: Management[J]. J Gastroenterol Hepatol, 2016,31:56-68.
[20]吴慧敏，汪芳裕.蛋白酶与自身消化在炎症性肠病发生机制中的作用与启示[J]. 医学研究生学报,2019,32(6):561-565.
[21]Dbkowski K,Graca-Pakulska K,Zawada I,et al. Clinical significance of endoscopic findings in the upper gastrointestinal tract in Crohn’s disease[J]. Scand J Gastroenterol,2019, 54(9): 1075-1080.
[22]印中鹏，宋令雄，王苏梦，等. 血浆抗凝血酶Ⅲ和血清IL-6与降钙素原对判断克罗恩病活动性的临床价值[J]. 东南国防医药, 2018, 20(1): 22-25.
[23]高闯，杜晓博，王丹丹，等. 白细胞介素22与炎症性肠病的研究进展[J]. 医学研究生学报, 2018, 31(11): 1196-1200.
[24]Cazacu SM,Ghilu �瘙 塂 i MC,Ivan ET,et al. An unusual onset of Crohn’s disease with oral aphthosis, giant esophageal ulcers and serological markers of cytomegalovirus and herpes virus infection: a case report and review of the literature.[J]. Rom J Morphol Embryol, 2019, 60(2): 659-665.
[25]Bettenworth D,Mücke MM,Lopez R,et al. Efficacy of Endoscopic Dilation of Gastroduodenal Crohn’s Disease Strictures: A Systematic Review and Meta-Analysis of Individual Patient Data.[J]. Clin Gastroenterol Hepatol,2019,17(12): 2514-2522.
[26]Iborra M,Juliá B,Martín Arranz MD,et al. Management and outcomes of patients with Crohn’s disease with first vs multiple surgeries: results from the PRACTICROHN study[J]. Gastroenterol Rep, 2019, 7(6): 411-418.

相似文献/References:

[1]薛 松,魏 磊,程 文,等.克罗恩病膀胱瘘3例报告[J].医学研究与战创伤救治(原医学研究生学报),2013,15(01):64.
[2]王珂,徐金中,黄迎春,等.外科加速康复团队在护理克罗恩病患者中的应用与效果观察[J].医学研究与战创伤救治(原医学研究生学报),2017,19(03):311.[doi:10.3969/j.issn.1672-271X.2017.03.023]
[3]印中鹏,宋令雄,王苏梦,等.血浆抗凝血酶Ⅲ和血清IL-6与降钙素原对判断克罗恩病活动性的临床价值[J].医学研究与战创伤救治(原医学研究生学报),2018,20(01):22.[doi:10.3969/j.issn.1672-271X.2018.01.005]
　YIN Zhong-peng,SONG Ling-xiong,WANG Su-meng,et al.Clinical value of plasma AT-Ⅲ and serum PCT, IL-6 levels and the evaluations of disease activity in Crohn′s disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2018,20(4):22.[doi:10.3969/j.issn.1672-271X.2018.01.005]
[4]奉婧,魏娟,汪芳裕.克罗恩病合并腹盆腔脓肿的内科治疗进展[J].医学研究与战创伤救治(原医学研究生学报),2022,24(1):54.[doi:10.3969/j.issn.1672-271X.2022.01.012]
　FENG Jing,WEI Juan,WANG Fang-yu.Progress in medical treatment of abdominal and pelvic abscess in Crohn’s disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(4):54.[doi:10.3969/j.issn.1672-271X.2022.01.012]

备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81873559）
更新日期/Last Update: 2020-07-13