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[1]黄昌萍,韩克.卵巢子宫内膜异位囊肿剥除术后血清AMH、雌二醇和窦卵泡数水平与子宫内膜容受性相关性研究[J].医学研究与战创伤救治(原医学研究生学报),2020,22(5):501-504.[doi:10.3969/j.issn.1672-271X.2020.05.011]
　HUANG Chang-ping,HAN Ke.Study on the relationship between the levels of serum anti-Mullerian hormone, estradiol, the number of antral follicles and endometrial receptivity after removal of ovarian endometriotic cyst[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(5):501-504.[doi:10.3969/j.issn.1672-271X.2020.05.011]
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卵巢子宫内膜异位囊肿剥除术后血清AMH、雌二醇和窦卵泡数水平与子宫内膜容受性相关性研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年5期
页码:
501-504
栏目:
临床研究
出版日期:
2020-09-09

文章信息/Info

Title:
Study on the relationship between the levels of serum anti-Mullerian hormone, estradiol, the number of antral follicles and endometrial receptivity after removal of ovarian endometriotic cyst
作者:
黄昌萍; 韩克
作者单位：210008南京,南京医科大学鼓楼临床医学院妇产科[黄昌萍（现在连云港市第二人民医院妇产科工作）、韩克]
Author(s):
HUANG Chang-ping;  HAN Ke
(Department of Gynecology, Nanjing Medical University Drum Tower Clinical Medical School, Nanjing 210008, Jiangsu, China)
关键词:
抗苗勒氏管激素; 雌二醇; 窦卵泡数; 子宫内膜容受性; 卵巢储备功能; 卵巢子宫内膜异位囊肿
Keywords:
anti-mullerian aormone;  estradiol;  number of antral follicles;  endometrial receptivity;  ovarian reserve function;  ovarian endometriosis cyst
分类号:
R711.4
DOI:
10.3969/j.issn.1672-271X.2020.05.011
文献标志码:
A
摘要:
目的检测血清抗苗勒氏管激素(AMH)、雌二醇（E2）水平和基础窦卵泡数(AFC)用于探讨卵巢子宫内膜异位囊肿患者行腹腔镜剥除术后导致子宫内膜容受性的改变，研究血清AMH、E2、AFC水平与子宫内膜容受性相关性，探讨子宫内膜容受性与卵巢储备功能的关系。方法选择2016年10月至2017年10月连云港市第二人民医院收治的卵巢子宫内膜异位囊肿行腹腔镜剥除术患者60例作为囊肿组，以同期健康体检超声提示无卵巢囊肿、月经周期规律的健康女性60例作为对照组。术后6个月分别检测2组血清AMH、E2水平和AFC并进行分析，同时对不同子宫内膜容受性患者的血清AMH、E2水平和AFC值进行比较。结果囊肿组患者的血清AMH水平[（0.82±0.35）ng/mL]明显低于对照组[（0.87±0.42）ng/mL]，差异有统计学意义（P＜0.05）。囊肿组A、B、C不同等级子宫内膜容受性的患者AMH平均值分别为(0.88±0.14)、(0.80±0.04)、(0.70±0.63) ng/mL，E2平均值分别为(1029.96±7.20)、(966.89±7.45)、(896.08±8.21) pg/mL，AFC的平均值分别其为(3.28±1.01)、(3.14±0.83)、(3.01±1.05)个。随着血清AMH、E2和AFC水平显著下降，子宫内膜容受性相应降低，血清AMH、E2和AFC水平与子宫内膜容受性呈现显著正相关（相关系数分别为1.259、1.347、1.401），差异有统计学意义（P＜0.01）。血清AMH、E2及AFC均为子宫内膜容受性的危险因素（P<0.01）。结论腹腔镜卵巢子宫内膜异位囊肿剥除术后进行血清AMH、E2和AFC检测，对于临床预测患者的卵巢储备功能及子宫内膜容受性具有积极意义。
Abstract:
ObjectiveThe serum levels of anti-Mullerian hormone (AMH), Estradiol (E2) and the number of antral follicles (AFC) were used to study the change of endometrial receptivity in patients with ovarian endometriosis cyst after laparoscopic removal. To study the relationship between endometrial receptivity and ovarian reserve function, the correlation between AMH, E2, AFC and endometrial receptivity was analyzed.MethodsFrom October 2016 to October 2017, 60 patients with ovarian endometriosis cyst with laparoscopic removal treated in Lianyungang Second Hospital were enrolled as the cyst group, and 60 healthy women in the same period as the control group. The levels of AMH, E2 and AFC in two groups were measured and analyzed. The levels of AMH, E2 and AFC in different endometrial receptive patients were compared.ResultsAMH level in the cyst group[（0.82±0.35）ng/mL] was significantly lower than that in the control group [（0.87±0.42）ng/mL] (P<0.05). In A, B, C three different levels of endometrialreceptivity of the cyst group, the mean of AMH were (0.88±0.14)，(0.80±0.04) and (0.70±0.63) ng/mL, E2 were (1029.96±7.20)，(966.89±7.45) and (896.08±8.21) pg/mL，AFC were (3.28±1.01)，(3.14±0.83) and (3.01±1.05)， respectively. With the decrease of serum AMH, E2 and AFC, the endometrial receptivity was decreased. The serum AMH, E2 and AFC levels were significantly correlated with endometrial receptivity，with correlation coefficient 1.259, 1.347, 1.401, respectively (P<0.01). Serum AMH, E2 and AFC were independent risk factors for endometrial receptivity (P<0.01).ConclusionThe detection of serum AMH, E2 and AFC after laparoscopic removal of ovarian endometriosis cyst is beneficial to the clinical prediction of ovarian reserve function and endometrial receptivity.

参考文献/References:

[1]杨泽星, 朱琼媛, 赵富鲜, 等. 早卵泡期血清抗苗勒管激素水平在预测卵巢低反应中的价值探讨[J]. 实用妇产科杂志, 2016, 32(8):593-596.
[2]王利娟，阮祥燕，崔亚美,等. 多囊卵巢综合征不同表型的血清抗苗勒管激素水平特征的分析[J]. 首都医科大学学报, 2016, 37(4):444-448.
[3]于晓莉, 赵丽文, 张烨敏. 黄体中期血清孕酮测定和子宫内膜活检在不孕症诊断中的意义[J]. 东南国防医药, 2010，12(5):401-403.
[4]朱颖春, 孙海翔, 王慧焱, 等. B超下子宫内膜形态分型对冷冻胚胎移植结局的影响[J]. 医学研究生学报, 2011, 24(9):948-951.
[5]陈颖, 陆娄恺奕, 岳朝艳, 等. 抗苗勒管激素与不同表型多囊卵巢综合征发病特征的相关性分析[J]. 生殖与避孕, 2017, 37(6):433-436.
[6]涂皎, 肖雁冰, 曹丽, 等. 全子宫与次全子宫切除术治疗子宫肌瘤对女性卵巢功能的影响[J]. 实用妇产科杂志, 2016, 32(4):278-281.
[7]Giudice LC,Kao LC.Endometriosis[J]. Lancet, 2003, 364(9447):1789-1799.
[8]Gonen Y, Casper RF. Prediction of implantation by the sonographic appearance of the endometrium during controlled ovarian stimulation for in vitro fertilization (IVF)[J]. J In Vitro Fert Embryo Transf，1990, 7(3):146-152.
[9]王萍, 邵渝, 林辉, 等. 化痰调经方联合达英-35治疗多囊卵巢综合征痰湿阻滞证的临床研究[J]. 北京中医药大学学报, 2017, 40(1):77-82.
[10]Wenners A，Grambach J，Koss J, et al. Reduced ovarian reserve in young early breast cancer patients: preliminary data from a prospective cohort trial[J]. Cancer, 2017, 17(1):632-633.
[11]Chen Y，Ye B，Yang X, et al. Predicting the outcome of different protocols of in vitro fertilization with anti-Muüllerian hormone levels in patients with polycystic ovary syndrome[J]. J Int Med Res, 2017, 45(3):1138-1147.
[12]Sahin Ersoy G, Turhan OT, Sakin O, et al. Comparison of the long-term effects of single-dose methotrexate and salpingectomy on ovarian reserve in terms of anti-müllerian hormone levels[J].Hum Fertil (Camb), 2016, 19(4): 262-267.
[13]Maculan R, Pinto TLC, Moreira GM, et al. Anti-Müllerian Hormone (AMH), antral follicle count (AFC), external morphometrics and fertility in Tabapua cows[J]. Anim Reprod Sci, 2018,189:84-92.
[14]何艺磊, 李蓉, 乔杰. 抗苗勒氏管激素与卵巢储备及反应性相关研究进展[J]. 生殖与避孕, 2016, 36(8):653-659.
[15]Cui LL，Sheng Y，Sun M, et al. Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian Hormone[J]. PLoS One, 2016, 11(6):e0156130. DOI: 10.1371/journal.pone.0156130.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2020-09-09