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[1]刘小平,林玉柱,赵勇,等.菟丝子乳膏治疗带状疱疹的临床疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2021,23(01):12-16.[doi:10.3969/j.issn.1672-271X.2021.01.001]
 LIU Xiao-ping,LIN Yu-zhu,ZHAO Yong,et al.Clinical efficacy observation of Cuscuta cream for the treatment of herpes zoster[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(01):12-16.[doi:10.3969/j.issn.1672-271X.2021.01.001]
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菟丝子乳膏治疗带状疱疹的临床疗效观察()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年01期
页码:
12-16
栏目:
临床研究
出版日期:
2021-01-20

文章信息/Info

Title:
Clinical efficacy observation of Cuscuta cream for the treatment of herpes zoster
作者:
刘小平林玉柱赵勇朱斌范远飞赵娜娜杨阳
作者单位:221004徐州,解放军陆军第七十一集团军医院/徐州医科大学附属淮海医院皮肤科(刘小平、范远飞),药剂科(林玉柱、朱斌、赵娜娜、杨阳),院办(赵勇)
Author(s):
LIU Xiao-ping1 LIN Yu-zhu2 ZHAO Yong3 ZHU Bin2 FAN Yuan-fei1 ZHAO Na-na2 YANG Yang2
(1. Department of Dermatology, 2. Department of Pharmacy, 3. The Hospital Office, the 71st Group Army Hospital of CPLA Army/the Affiliated Huaihai Hospital of Xuzhou Medical University, Xuzhou 221004, Jiangsu, China)
关键词:
带状疱疹菟丝子乳膏临床疗效菟丝子
Keywords:
herpes zoster Cuscuta cream clinical efficacy Semen Cuscutae
分类号:
R752.12;R275.9
DOI:
10.3969/j.issn.1672-271X.2021.01.001
文献标志码:
A
摘要:
目的在带状疱疹常规治疗基础上,观察外用菟丝子乳膏治疗带状疱疹的临床疗效及安全性。方法2019年2-5月于陆军第七十一集团军医院皮肤科就诊的39例带状疱疹患者,采用随机数字表法分为常规治疗组11例、蛇药片组11例和菟丝子乳膏组17例,各组患者除采取常规治疗手段外,分别以炉甘石洗剂、季德胜蛇药片和菟丝子乳膏作为外用药物,在治疗后第1、4、7、10、14、28天观察并记录各组患者疱疹处临床症状变化情况,包括疱疹完全结痂时间、疼痛消除时间以及疼痛程度,计算各组患者治疗后28 d的总有效率,观察不良反应发生情况。结果治疗后,菟丝子乳膏组患者的疱疹完全结痂时间为(6.12±2.15)d,显著低于常规治疗组(P<0.01);疼痛消除时间为(7.41±3.18)d,显著低于常规治疗组(P<0.01)及蛇药片组(P<0.05)。治疗后第7天,菟丝子乳膏组患者的口述分级评分法(VRS)疼痛评价显著低于常规治疗组(P<0.05);治疗后第10天、第14天,菟丝子乳膏组患者的数字评价量表法(NRS)疼痛评分显著低于其他2组患者(P<0.05)。经过28 d的治疗,常规治疗组、蛇药片组、菟丝子乳膏组患者的治疗总有效率分别为81.82%、90.91%、100.00%,组间比较差异无统计学意义(P>0.05)。结论菟丝子乳膏具有较好的收敛作用和止痛作用,能够促进疱疹结痂,快速缓解疼痛,有效消除疼痛,缩短疼痛时间及病程,改善患者生活质量,且易于涂布和吸收,使用方便,患者依从性较好,适用于带状疱疹的临床治疗与推广。
Abstract:
ObjectiveIn order to observe the clinical efficacy and safety of Cuscuta cream for the treatment of herpes zoster on the basis of conventional treatment.MethodsThirty-nine patients with herpes zoster in the 71st Group Army Hospital of CPLA Army from February to May 2019 were randomly divided into the conventional treatment group, Sheyao tablets group and Cuscuta cream group. In addition to conventional treatment, patients in each group were paid calamine lotion, Jidesheng Sheyao tablets and Cuscuta cream as topical drugs, respectively. On the 1st, 4th, 7th, 10th, 14th and 28th day after treatment, the clinical symptoms and adverse reactions of the patients in each group were observed and recorded.ResultsAfter treatment, the herpes complete scab formation time in Cuscuta cream group was (6.12±2.15) d, which was significantly lower than that in the conventional treatment group (P<0.01). The pain elimination time in Cuscuta cream group was (7.41±3.18) d, which was significantly lower than those in the conven-tional treatment group (P<0.01) and Sheyao tablets group (P<0.05). On the 7th day after treatment, the pain evaluation of verbal rating scale (VRS) in Cuscuta cream group was noticeably lower than that in the conventional treatment group (P<0.05). On the 10th and 14th days after treatment, the pain evaluation of numerical rating scale (NRS) in Cuscuta cream group was considerably lower than those in the other two groups (P<0.05). After 28 days of treatment, the total treatment effective rate in the conventional treatment group, Sheyao tablets group, and Cuscuta cream group was 81.82%, 90.91%, and 100.00%, respectively. There was no statistically significant difference (P >0.05).ConclusionCuscuta cream has preferable astringent and analgesic effects, which could promote herpes scab formation, relieve pain quickly and eliminate pain effectively. Cuscuta cream could shorten the pain time and duration, improve the quality of patient lives.

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相似文献/References:

[1]李芳,贾立华,马维娜.碘酊与如意金黄散外敷治疗带状疱疹疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2010,12(05):442.
[2]乔 丽,王红现,田 蓉,等.更昔洛韦联合半导体激光治疗带状疱疹临床研究[J].医学研究与战创伤救治(原医学研究生学报),2010,12(04):312.
 QIAO Li,WANG Hong-Xian,TIAN Rong,et al.Treatment of herpes zoster with ganciclovir and semiconductor laser[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(01):312.
[3]朱小蔚.甲钴胺辅助治疗高龄老人带状疱疹神经痛55例[J].医学研究与战创伤救治(原医学研究生学报),2009,11(05):437.

备注/Memo

备注/Memo:
基金项目:解放军陆军科技英才培育工程资助项目(政干〔2019〕340号);徐州市医学青年后备人才工程资助项目(徐卫科教〔2015〕7号)
更新日期/Last Update: 2021-01-26