|本期目录/Table of Contents|

[1]黄明清,翁雨亭,方克伟.雌激素受体的生物学功能及其在骨骼肌发育和前列腺癌中作用的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2022,24(2):172-175.[doi:10.3969/j.issn.1672-271X.2022.02.013]
　HUANG Ming-qing,WENG Yu-ting,FANG Ke-wei.Advances in the study of the biological function of estrogen receptor and its role in skeletal muscle development and prostate cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(2):172-175.[doi:10.3969/j.issn.1672-271X.2022.02.013]
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雌激素受体的生物学功能及其在骨骼肌发育和前列腺癌中作用的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年2期
页码:
172-175
栏目:
综述
出版日期:
2022-03-20

文章信息/Info

Title:
Advances in the study of the biological function of estrogen receptor and its role in skeletal muscle development and prostate cancer
作者:
黄明清; 翁雨亭; 方克伟
作者单位：650101昆明，昆明医科大学第二附属医院泌尿外科（黄明清、翁雨亭、方克伟）
Author(s):
HUANG Ming-qing; WENG Yu-ting ;  FANG Ke-wei
（Department of Urology，Second Affiliated Hospital of Kunming Medical University，Kunming 650101，Yunnan，China）
关键词:
雌激素受体; 雌激素; 骨骼肌; 前列腺癌
Keywords:
estrogen receptor; estrogen; skeletal muscle; prostate cancer
分类号:
R737
DOI:
10.3969/j.issn.1672-271X.2022.02.013
文献标志码:
A
摘要:
雌激素受体（ER）是核受体家族中重要的一员，在多种组织中广泛表达，包括肌肉、乳腺、前列腺等。ER主要包括ERα 和ERβ，当雌激素与ER结合后，通过形成同源或异源二聚体进入细胞核中促进多种转录因子的激活，从而调节复杂、动态的基因网络。ER在调节细胞的增殖、凋亡和自噬等过程中发挥重要作用，且与多种疾病的发生与发展密切相关，因此，近年来逐渐成为研究的热点。文章就ER的结构、生物学功能及其在骨骼肌发育和前列腺癌中的作用进行综述。
Abstract:
Estrogen receptor is an important member of the nuclear receptor family and is widely expressed in various tissues, including muscle, breast, prostate, etc. Estrogen receptors mainly include ERα and ERβ. When estrogen binds to estrogen receptors, they enter the nucleus by forming homodimers or heterodimers to promote the activation of a variety of transcription factors, thereby regulating complex and dynamic gene networks. Estrogen receptor plays an important role in the regulation of cell proliferation, apoptosis and autophagy, and is closely related to the occurrence and development of a variety of diseases. Therefore, it has gradually become a research hotspot in recent years. This paper reviews the structure, biological function and role of estrogen receptor in skeletal muscle development and prostate cancer.

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　CHEN Ji-long,HE Bang-shun,PAN Yu-qin,et al.Association of gene polymorphisms of estrogen receptor alpha with endometriosis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(2):267.

备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81860127）；昆明医科大学研究生创新基金（2020S179）
更新日期/Last Update: 2022-04-18