|本期目录/Table of Contents|

[1]邓宏彬,于先强,李维勤.低分子肝素治疗重症急性胰腺炎研究进展[J].医学研究与战创伤救治(原医学研究生学报),2022,24(3):289-291.[doi:10.3969/j.issn.1672-271X.2022.03.014]
　DENG Hong-bin,YU Xian-qiang,LI Wei-qin.Research progress of low molecular weight heparin in the treatment of severe acute pancreatitis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(3):289-291.[doi:10.3969/j.issn.1672-271X.2022.03.014]
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低分子肝素治疗重症急性胰腺炎研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年3期
页码:
289-291
栏目:
综述
出版日期:
2022-06-30

文章信息/Info

Title:
Research progress of low molecular weight heparin in the treatment of severe acute pancreatitis
作者:
邓宏彬; 于先强; 李维勤
作者单位：210002南京，南京医科大学金陵临床医学院（东部战区总医院）重症医学科（邓宏彬、于先强、李维勤）
Author(s):
DENG Hong-bin;  YU Xian-qiang ;  LI Wei-qin
(Department of Critical Care Medicine, Jinling School of Clinical Medicine, Nanjing Medical University, General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China)
关键词:
急性胰腺炎; 低分子肝素; 凝血; 脓毒症
Keywords:
acute pancreatitis;  low molecular weight heparin;  coagulation;  sepsis
分类号:
R576
DOI:
10.3969/j.issn.1672-271X.2022.03.014
文献标志码:
A
摘要:
重型急性胰腺炎是病情进展的阶段，主要表现为凝血紊乱、复杂的炎性状态及血脂代谢异常等，从而很大程度影响疾病的治疗和预后。低分子肝素因其显著的抗凝、抗炎、降脂等多方面的药理作用而被广泛应用于重型急性胰腺炎的临床实践当中。然而目前的治疗机制方面的相关研究相对较少，文章主要就低分子肝素在重型急性胰腺炎的多方面治疗效果进行综述。
Abstract:
Severe acute pancreatitis is the progressive stage of pancreatitis. It is mainly manifested by coagulation disorders, complex inflammatory state and abnormal lipid metabolism, which greatly affects the treatment and leads to a bad prognosis. Low molecular weight heparin has been widely used in clinical practice of severe acute pancreatitis, due to its significant anti-coagulation, anti-inflammatory, lipid-lowering and other pharmacological effects. However, there are relatively few relevant studies on the therapeutic mechanism at present. Combining with the latest research on low molecular weight heparin, we reviewed its therapeutic effects in many aspects in severe acute pancreatitis.

参考文献/References:

[1]侯德坤,李书胜,巩腾飞. 低分子肝素的制备技术及临床应用进展[J]. 山东化工, 2020, 49(10): 52-57.
[2]Kleinschmidt K, Charles R. Pharmacology of low molecular weight heparins[J]. Emerg Med Clin North Am, 2001,19(4): 1025-1049.
[3]Hao C, Sun M, Wang HM, et al. Low molecular weight heparins and their clinical applications[J]. Prog Mol Biol Transl Sci, 2019, 163: 21-39.
[4]刘章,姬胜利. 低分子肝素的药理作用和临床应用研究进展[J]. 药物生物技术, 2014, 21(6): 573-578.
[5]Tang Y, Wang X, Li ZZ, et al. Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties[J]. Immunity, 2021, 54(3): 454-467.
[6]卢世云,潘秀珍. 重症急性胰腺炎发病机制研究现状[J]．世界华人消化杂志, 2011, 19(23)：2421-2425.
[7]Pal KM, Kasi PM, Tayyeb M, et al. Correlates of morbidity and mortality in severe necrotizing pancreatitis [J]. ISRN Surg, 2012, 2012:215193.
[8]于先强,柯路. 急性胰腺炎的凝血紊乱研究进展[J]. 东南国防医药, 2019, 21(2): 176-179.
[9]周守凤,沈曙光. 急性胰腺炎微循环障碍的机制及治疗进展[J]. 华南国防医学杂志，2019，33(6): 433-436.
[10]Qiu F, Lu XS, Huang YK. Effect of low molecular weight heparin on pancreatic micro-circulation in severe acute pancreatitis in a rodent model[J]. Chin Med J (Engl), 2007, 120(24): 2260-2263.
[11]Chen Y, Ke L, Meng L, et al. Endothelial markers are associated with pancreatic necrosis and overall prognosis in acute pancreatitis: A preliminary cohort study[J]. Pancreatology, 2017, 17(1): 45-50.
[12]Ping C,Yongping Z, Minmin Q, et al. Activated protein C improves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and thrombomodulin[J]. Dig Dis Sci, 2010, 55(6)：1599-1609.
[13]Matsumoto T, Wada H, Nobori T, et al. Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with disseminated intravascular coagulation[J]. Clin Appl Thromb Hemost, 2005, 11(4)：391-400.
[14]Zhang XP,Li ZJ,Zhang J. Inflammatory mediators and microcirculatory disturbance in acute pancreatitis[J]. Hepatobiliary Pancreat Dis Int, 2009, 8(4): 351-357.
[15]Zeng XH, Zhu SQ, Zhang SM, et al. Plasma endothelin and nitric oxide levels in patients with acute pancreatitis[J]. Hepatobiliary Pancreat Dis Int, 2002, 1(1): 140-142.
[16]王湘英,卢义展,张兴文,等. 低分子肝素对伴高脂血症急性坏死性胰腺炎大鼠PAF、ET-1/NO的影响[J]．世界华人消化杂志, 2012, 20(10)：856-860.
[17]Ke L,Ni HB,Tong ZH, et al. Efficacy of continuous regional arterial infusion with low-molecular-weight heparin for severe acute pancreatitis in a porcine model[J]. Shock, 2014, 41(5): 443-448.
[18]Mikami Y, Takeda K, Matsuda K, et al. Rat experimental model of continuous regional arterial infusion of protease inhibitor and its effects on severe acute pancreatitis[J]. Pancreas, 2005, 30（3）：248-253.
[19]Lu G, Tong Z, Ding Y, et al. Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice[J]. Biomed Res Int, 2016, 2016: 6089430.
[20]Munhoz-Filho CH, Batigália F, Funes HL, et al. Clinical and therapeutic correlations in patients with slight acute pancreatitis [J]. Arq Bras Cir Dig, 2015, 28(1): 24-27.
[21]Boxhoorn L,Voermans RP. Acute pancreatitis[J]. Lancet, 2020, 396(10252): 726-734.
[22]Qiu F, Lu XS, Huang YK. Effect of low molecular weight heparin on pancreatic micro-circulation in severe acutepancreatitis in a rodent model[J]. Chin Med J (Engl), 2007, 120(24): 2260-2263.
[23]张世龙,涂巧丽,石斌.低分子肝素区域动脉灌注治疗重症急性胰腺炎的实验研究[J]．中国普通外科杂志，2012，21(3)：290-294.
[24]Stigliano S, Sternby H,de Madaria E, et al. Early management of acute pancreatitis: A review of the best evidence[J]. Dig Liver Dis, 2017, 49(6): 585-594.
[25]Deng LH, Xue P, Xia Q, et al. Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis[J]. World J Gastroenterol, 2008, 14(28): 4558-4561.
[26]Moens L, Yengue YP, Assenmacher C. Intrascrotal Collection in an Acute Pancreatitis: A Case Report and Review of the Literature[J]. Case Rep Urol, 2016, 2016: 7534781.
[27]田时静,周发春. 低分子肝素治疗重症急性胰腺炎研究进展[J]. 重庆医学, 2014, 43(5): 625-627.
[28]司淑平,占强. 低分子肝素、胰岛素联合血浆置换治疗高脂血症性急性胰腺炎的疗效观察[J], 广西医科大学学报, 2016, 33(5): 808-811.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金(81870441)
更新日期/Last Update: 2022-06-21