|本期目录/Table of Contents|

[1]房智超,李佳敏,王树楷综述,等.组织驻留巨噬细胞在急性胰腺炎中的作用及靶向干预研究进展[J].医学研究与战创伤救治(原医学研究生学报),2023,25(3):301-306.[doi:10.3969/j.issn.1672-271X.2023.03.016]
　FANG Zhichao,LI Jiamin,WANG Shukai,et al.Advances in the role of tissue-resident macrophages in acute pancreatitis and targeted intervention[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2023,25(3):301-306.[doi:10.3969/j.issn.1672-271X.2023.03.016]
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组织驻留巨噬细胞在急性胰腺炎中的作用及靶向干预研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第25卷
期数:
2023年3期
页码:
301-306
栏目:
综述
出版日期:
2023-08-01

文章信息/Info

Title:
Advances in the role of tissue-resident macrophages in acute pancreatitis and targeted intervention
作者:
房智超; 李佳敏; 王树楷综述; 宋亮审校
作者单位：712046咸阳，陕西中医药大学第二临床医学院（房智超、王树楷），基础医学院（李佳敏），医学科研实验中心（宋亮）
Author(s):
FANG Zhichao1; LI Jiamin2; WANG Shukai1; SONG Liang3
(1.Second Clinical Medical College, 2. The Basic Medical College，3. The Medical Experiment Center，Shaanxi University of Chinese Medicine，Xianyang 712046，Shaanxi, China)
关键词:
巨噬细胞; 急性胰腺炎; 免疫调节; 炎症因子
Keywords:
macrophages; acute pancreatitis; immunomodulation; inflammatory factor
分类号:
R657.5+1
DOI:
10.3969/j.issn.1672-271X.2023.03.016
文献标志码:
A
摘要:
急性胰腺炎（AP）是一种发病急且致死率较高的急腹症，表现为多种因素诱发的胰腺损伤以及炎症细胞过度活化，严重时可导致全身炎症反应综合征和多器官功能障碍。作为先天免疫细胞，巨噬细胞是AP的核心因素，也是病程中细胞因子和趋化因子的主要产生部位。AP的严重程度与巨噬细胞参与的炎症级联反应密切相关，针对巨噬细胞的靶向干预可能成为阻断炎症过程、促进组织修复的关键。文章就AP中各驻留巨噬细胞的作用机制以及靶向干预后其表型功能变化进行综述。
Abstract:
Acute pancreatitis is an acute abdominal disease with sudden onset and high mortality. Multiple factors lead to pancreatic damage, and excessive activation of inflammatory cells, which triggers systemic inflammatory response syndrome and multiple organ dysfunction in severe cases. As innate immune cells, macrophages have been found to be core players in AP and the major producers of pro-inflammatory cytokines and chemokines during AP. The severity of AP is closely related to the inflammatory cascade in which macrophages participate. Targeted intervention through macrophages may become indispensable to block the inflammatory process and promote tissue repair in AP. Therefore, this review summarizes the mechanism of action of resident macrophages during AP and their phenotypic functional changes after targeted intervention, providing new ideas and methods for dissecting the pathogenesis and prevention of AP.

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备注/Memo

备注/Memo:
基金项目：陕西省科技厅重点研发计划项目（2019SF-294）；陕西省“特支计划”区域发展人才项目（2017）；陕西中医药大学胰、肝疾病的分子机制及中西医防治创新团队项目（2019-YL14）
更新日期/Last Update: 2023-08-24