[1]童成刚,崔云惠,于连荣,等.曲美他嗪治疗老年冠心病稳定性心绞痛的疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2012,14(02):138-140.
　TONG Cheng-gang,CUI Yun-hui,YU Lian-rong,et al.The clinical observation of trimetazidine treatment of coronary heart disease with stable angina in aged patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(02):138-140.
点击复制

曲美他嗪治疗老年冠心病稳定性心绞痛的疗效观察()

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第14卷
期数:
2012年02期
页码:
138-140
栏目:
出版日期:
2012-03-20

文章信息/Info

Title:
The clinical observation of trimetazidine treatment of coronary heart disease with stable angina in aged patients
文章编号:
1672-271X(2012)02-0138-03
作者:
童成刚; 崔云惠; 于连荣; 刘 赟
221004 江苏徐州,解放军97医院干部病房
Author(s):
TONG Cheng-gang; CUI Yun-hui; YU Lian-rong; LIU Yun.
Department of Cadre Ward,97 Hospital of PLA,Xuzhu,Jiangsu 221004,China
关键词:
稳定性心绞痛; 冠心病; 曲美他嗪; 老年人
Keywords:
stable angina;  coronary heart disease;  trimetazidine;  aged
分类号:
R541.42
DOI:
-
文献标志码:
A
摘要:
目的 分析研究曲美他嗪治疗老年冠心病稳定性心绞痛的临床疗效。方法 选择老年冠心病稳定性心绞痛62例，随机分为治疗组和对照组各31例，对照组常规服用阿司匹林、β-受体阻滞剂、硝酸酯类和他汀类药物，治疗组在对照组治疗的基础上加曲美他嗪，疗程均为8周；比较两组患者治疗前后每周心绞痛发作次数、硝酸甘油用量及心电图、血压、心率变化等指标。结果 治疗8周后，临床疗效治疗组(90.32%)明显优于对照组(70.97%)，心电图改善情况治疗组(83.87%)优于对照组(67.74%)，但差异均无统计学意义；两组患者心绞痛发作次数、硝酸甘油消耗量均较治疗前显著减少，与对照组比较，治疗组减少更明显(P<0.05)；治疗期间两组均未见明显不良反应发生。结论 曲美他嗪治疗老年冠心病稳定性心绞痛疗效确切，可有效改善心绞痛症状，值得临床推广使用。
Abstract:
Objective To explore the clinical curative effect of trimetazidine treatment on senile coronary stable angina.Methods 62 patients with stable angina were randomly divided into treatment group and control group,31 cases in each group.The control group received regularly aspirin,β-blockers,nitrates and statins for 8 weeks,the treatment group was administered trimetazidine in addition to conventional treatment.The anginal attacks,nitroglycerin consumption and electrocardiogram,heart rate and blood pressure changes in two groups of patients before and after the treatment were compared weekly.Results Anginal attacks,nitroglycerin consumption were significantly reduced after 8 weeks in two groups.The effect in treatment group was better than control group(P<0.05).Clinical effect in treatment group(90.32%) was remarkably superior to that in control group(70.97%).Electrocardiogram ischemic changes in treatment group(83.87%) were better than that in control group(67.74%).Changes of heart rate and blood pressure in two groups were not significant.No drug-related adverse reactions were found in both groups.Conclusion Trimetazidine can impove the senile coronary heart disease with stable angina in patients and is valuable to be spread broadly in clinic．

参考文献/References:

[1]中华医学会心血管病学分会，中华心血管病杂志编辑委员会．慢性稳定性心绞痛诊断与治疗指南[J]．中华心血管病杂志，2007，35(5):195-206．
[2]张海红.曲美他嗪治疗老年人冠心病心绞痛疗效观察[J]．海南医学，2006，17(4):72-73.
[3]董吉云，杨志勇，苗年海，等.曲美他嗪治疗老年冠心病稳定性心绞痛临床观察[J]．安徽医学，2011，32(4):463-465.
[4]尹 炯.血浆脂联素水平与冠心病的相关性[J]．东南国防医药，2007，9(6):403-403，419.
[5]韩 洁．硝酸甘油不良反应[J]．中国误诊学杂志，2007，7(7):1659-1660.
[6]戴 军，陈 凌．曲美他嗪在心血管疾病中的临床作用[J]．心血管病学进展，2001，22(5):278-280．
[7]徐怀东，李雪梅．曲美他嗪药理学与临床研究进展[J]．临床误诊误治，2010，23(3):278-280.
[8]邓名珉．曲美他嗪联合辛伐他汀治疗不稳定型心绞痛临床观察[J]．中国医药导报，2010，20(7):57-58．
[9]高秀华．曲美他嗪治疗慢性充血性心力衰竭临床效果观察[J]．临床误诊误治，2008，21(6):3-5．
[10]周咏梅．BNP检测对曲美他嗪治疗充血性心力衰竭的疗效评价[J]．中国医药导报，2010，7(22):29-30．
[11]田艳珍，王永亮，吴永全，等．曲美他嗪在急性冠脉综合征及心功能不全应用中的新进展[J]．中国医药导刊，2010，12(8):1360-1361．
[12]屈 健，项 军，赵 勇，等．75岁以上老年冠心病患者的冠状动脉介入治疗[J]．东南国防医药，2007，9(2):88-90．
[13]中国曲美他嗪多中心临床研究协作组．曲美他嗪对稳定性劳力型心绞痛的疗效观察[J]．中华心血管病杂志，2000，28(5):339-341．

相似文献/References:

[1]任绍学,何幼英,罗助荣.瑞舒伐他汀钙治疗冠心病合并高脂血症疗效分析[J].医学研究与战创伤救治(原医学研究生学报),2013,15(04):403.[doi:10.3969/j.issn.1672-271X.2013.04.029 ]
[2]苑小历,游云鹏,潘士勇,等.MTHFR基因多态性及同型半胱氨酸与老年冠心病的相关性[J].医学研究与战创伤救治(原医学研究生学报),2012,14(04):320.
　YUAN Xiao-li,YOU Yun-peng,PAN Shi-yong,et al.The correlation between MTHFR gene polymorphisms and levels of plasma homocysteine (Hcy) in elderly patients with coronary heart disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(02):320.
[3]李晓红,陈兴灿,赵凯宇.宝石能谱CT冠状动脉成像在冠心病诊断中的应用[J].医学研究与战创伤救治(原医学研究生学报),2012,14(04):322.
　LI Xiao-hong,CHEN Xing-can,ZHAO Kai-yu.Evaluation of gemstone spectral CT coronary angiography in diagnosis of coronary heart disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(02):322.
[4]王兴元,曹红兵,周红霞,等.前驱糖尿病对冠心病侧支循环形成的影响[J].医学研究与战创伤救治(原医学研究生学报),2011,13(04):327.
　WANG Xing-yuan,CAO Hong-bin,ZHOU Hong-xia,et al.Influence of prediabetes on coronary collateral formation in patients with documented occlude coronary arteries[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(02):327.
[5]李晓萍,方石虎,张圆圆.经皮冠状动脉介入联合主动脉内球囊反搏术的临床护理[J].医学研究与战创伤救治(原医学研究生学报),2011,13(04):333.
　LI Xiao-ping,FANG Shi-hu,ZHANG Yuan-yuan..The nursing care of IABP for coronary artery disease patients after PCI[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(02):333.
[6]龚建明,李以宏,雷军平.氯吡格雷与质子泵抑制剂相互作用的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2011,13(05):440.
[7]林 杰,陈力平,肖 立,等.同型半胱氨酸、C反应蛋白与血脂相关指标对冠心病诊断的比较[J].医学研究与战创伤救治(原医学研究生学报),2011,13(06):509.
　LIN Jie,CHEN Li-ping,XIAO Li,et al.Evaluation of serum homocysteine,C-reactive protein and various lipid lipoprotein in diagnosis of coronary heart disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(02):509.
[8]董晓敏,卢瑜.临床路径在冠心病专病疗养中的应用[J].医学研究与战创伤救治(原医学研究生学报),2010,12(06):534.
[9]李路军,许万兵,曹江晨.脉络宁治疗老年冠心病48例[J].医学研究与战创伤救治(原医学研究生学报),2010,12(04):349.
[10]仓书华,邢继成,江淑芳.冠心病患者缺血修饰白蛋白水平初探[J].医学研究与战创伤救治(原医学研究生学报),2008,10(01):48.

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2012-03-20