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[1]金洁,王俊,王磊,等.冠心病患者血清同型半胱氨酸、miR-1、miR-126和miR-208的相关性分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(04):363-366.[doi:10.3969/j.issn.1672-271X.2014.04.009]
　JIN Jie,WANG Jun,WANG Lei,et al.Correlation analysis of Hcy,miR-1,miR-126 and miR-208 in coronary heart disease patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(04):363-366.[doi:10.3969/j.issn.1672-271X.2014.04.009]
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冠心病患者血清同型半胱氨酸、miR-1、miR-126和miR-208的相关性分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年04期
页码:
363-366
栏目:
出版日期:
2014-07-31

文章信息/Info

Title:
Correlation analysis of Hcy,miR-1,miR-126 and miR-208 in coronary heart disease patients
作者:
金洁1; 王俊2; 王磊2; 蔡晓敏2; 王立军2; 宫剑滨2
1.310007 浙江杭州，空军杭州航空医学鉴定训练中心内科;2.210002 江苏南京，南京大学医学院(南京军区南京总医院)心脏内科
Author(s):
JIN Jie1; WANG Jun2; WANG Lei2; CAI Xiao-min2; WANG Li-jun2; GONG Jian-bin2.
1.Department of Internal,Hangzhou Air Force Medical Appraisement Center,Zhejiang 310007,China;2.Department of Cardiology,Medical School of Nanjing University,Nanjing General Hospital of Nanjing Military Command,Nanjing,Jiangsu 210002,China
关键词:
冠心病; 同型半胱氨酸; 微小核糖核酸-1; 微小核糖核酸-126; 微小核糖核酸-208
Keywords:
coronary heart disease;  homocysteine;  miR-1;  miR-126;  miR-208
分类号:
R541.4
DOI:
10.3969/j.issn.1672-271X.2014.04.009
文献标志码:
A
摘要:
目的 结合冠状动脉狭窄程度，探讨冠心病患者血清同型半胱氨酸(Hcy)与微小RNA(miR-1、miR-126及miR-208)之间的相互关系。方法 选取行冠脉造影术的患者共102名，根据造影结果分为对照组和观察组，检测Hcy、miR-1、miR-126及miR-208水平，同时对冠脉造影结果进行评价并计算Gensini积分，应用相关及线性回归分析Hcy、miRNA(miR-1、miR-126、miR-208)以及Gensini积分的相互关系。结果 观察组血清Hcy、miRNA(miR-1、miR-126、miR-208)水平均高于对照组，血清Hcy、miR-1和miR-126水平分别与Gensini积分呈正相关[相关系数(r)分别为0.575、0.649、0.499，P均＜0.01]，偏相关分析校正后它们之间仍然呈正相关(r’分别为0.693、0.621、0.532，P均<0.05)；而血清Hcy与miR-1、miR-126水平亦呈正相关(r分别为0.513、0.56，P均＜0.01)，偏相关分析校正后排除年龄，体重指数，高血压和高脂血症病史的影响，其间仍然呈正相关(r’分别为0.599、0.614，P均<0.05)，而与miR-208无显著相关性。结论 血清Hcy、miRNA(miR-1、miR-126、miR-208)均是评价冠心病的独立危险因素，其水平均随着冠脉病变严重程度的加重而增加。
Abstract:
Objective To study the correlation between miRNA (miR-1,miR-126,miR-208) and homocysteine (Hcy) conbining on the severity of stenosis of coronary artery.Methods One hundred and two patients undergoing quantitative coronary angiography were involved in this study.Patients were categorized into control group and coronary artery disease (CAD) group.The concentration of Hcy and miRNA (miR-1,miR-126,miR-208) were measured.The severity scale of coronary artery stenosis was quantitatively assessed according to coronary angiography by Gensini score.The correlation analysis and linear regression were used to show the association of Hcy,miRNA (miR-1,miR-126 and miR-208) and Gensini score.Results The concentration of Hcy and miRNA (miR-1,miR-126 and miR-208) were higher in CAD group than those in control group.In the correlation analysis,Gensini score was positively associated with Hcy,miR-1 and miR-126 (r=0.575,0.649,and 0.499,P＜0.01) and the positive correlation between them remained significant after revising partial correlation analysis (r'=0.693,0.621,and 0.532,P<0.05).Hcy was influenced by miR-1 and miR-126 both in the Spearson correlation analysis (r=0.513,0.56,P＜0.01) and partial correlation analysis (r'=0.599,0.614,P<0.05),but not by miR-208.Conclusion Hcy,miRNA (miR-1,miR-126 and miR-208) are independent risk factor for coronary heart disease and are increased along with stenosis of coronary arteries.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2014-07-20